Document Detail


The incident user design in comparative effectiveness research.
MedLine Citation:
PMID:  23023988     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Comparative effectiveness research includes cohort studies and registries of interventions. When investigators design such studies, how important is it to follow patients from the day they initiated treatment with the study interventions? Our article considers this question and related issues to start a dialogue on the value of the incident user design in comparative effectiveness research. By incident user design, we mean a study that sets the cohort's inception date according to patients' new use of an intervention. In contrast, most epidemiologic studies enroll patients who were currently or recently using an intervention when follow-up began. We take the incident user design as a reasonable default strategy because it reduces biases that can impact non-randomized studies, especially when investigators use healthcare databases. We review case studies where investigators have explored the consequences of designing a cohort study by restricting to incident users, but most of the discussion has been informed by expert opinion, not by systematic evidence. Published 2012. This article is a U.S. Government work and is in the public domain in the USA.
Authors:
Eric S Johnson; Barbara A Bartman; Becky A Briesacher; Neil S Fleming; Tobias Gerhard; Cynthia J Kornegay; Parivash Nourjah; Brian Sauer; Glen T Schumock; Art Sedrakyan; Til Stürmer; Suzanne L West; Sebastian Schneeweiss
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-1
Journal Detail:
Title:  Pharmacoepidemiology and drug safety     Volume:  -     ISSN:  1099-1557     ISO Abbreviation:  Pharmacoepidemiol Drug Saf     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9208369     Medline TA:  Pharmacoepidemiol Drug Saf     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Published 2012. This article is a U.S. Government work and is in the public domain in the USA.
Affiliation:
The Center for Health Research, Kaiser Permanente, Portland, Oregon, USA.
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