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The incidence of various antiphospholipid antibodies, measured by commercial-based laboratory, with recurrent spontenous abortion and the impact of their profiles on reproductive outcome with active anticoagulant therapy.
MedLine Citation:
PMID:  22523696     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Objective. To investigate the incidence of various antiphospholipid antibodies (aPLs), measured by commercial-based laboratory, with recurrent spontaneous abortion (RSA) patients and the impact of the species, isotype, titer, and number of positive aPLs on reproductive outcome in Japanese. Method. In this retrospective cohort study, 263 patients with RSA without possible causes were investigated. Of 131 patients with one or more positive aPL, 82 pregnant women under anticoagulant therapy were evaluated. Results. The incidence of various aPLs was almost consistent with previous report. Overall, successful pregnancy rate with anticoagulant therapy was 91.4% regardless of aPL profiles. There was no significant difference in the pregnancy maintenance rate between IgG and IgM groups or single positive and multiple positive groups, but there was a tendency for the rate with aspirin to be lower than with aspirin plus heparin in IgG group. Conclusion. aPL profile did not affect the pregnancy maintenance rate when anticoagulant therapy was actively introduced, however in IgG group, we recommend combination therapy with aspirin and heparin.
Authors:
Nagayoshi Umehara; Tadao Tanaka
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Publication Detail:
Type:  Journal Article     Date:  2012-03-12
Journal Detail:
Title:  ISRN obstetrics and gynecology     Volume:  2012     ISSN:  2090-4444     ISO Abbreviation:  ISRN Obstet Gynecol     Publication Date:  2012  
Date Detail:
Created Date:  2012-04-23     Completed Date:  2012-08-23     Revised Date:  2013-03-04    
Medline Journal Info:
Nlm Unique ID:  101558763     Medline TA:  ISRN Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  819356     Citation Subset:  -    
Affiliation:
Department of Obstetrics and Gynecology, The Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo 105-8461, Japan.
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