Document Detail


The incidence of thyroid function abnormalities in patients attending an outpatient lipid clinic.
MedLine Citation:
PMID:  10319942     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thyroid disorders are known to influence lipoprotein metabolism. In the current study we examined the incidence of thyroid function abnormalities in patients attending our outpatient lipid clinic. During the last 2 years, 248 patients were admitted to our lipid clinic for the diagnosis and management of dyslipidemia. In all cases, a detailed medical history was obtained and a thorough physical examination was performed with emphasis on the presence of symptoms/signs indicative of underlying thyroid diseases. In addition to lipid parameters, thyrotropin (TSH) and free thyroxine (FT4) levels were measured in a fasting blood sample. Seven female asymptomatic patients (2.8%) had frank biochemical hypothyroidism, and 11 patients (9 female, 2 male) (4.4%) had subclinical hypothyroidism with TSH levels between 5.8-19 mU/L. After restoration of a euthyroid state with levothyroxine therapy, no significant changes in serum lipid parameters were observed in the whole group of patients with subclinical hypothyroidism. However, in 4 patients with TSH levels >12 mU/L relatively small doses of levothyroxine (75 microg/day) were followed by a significant improvement of serum lipid profile. Interestingly, 3 patients exhibited clinical or subclinical hyperthyroidism that influenced serum lipid parameters as well as the effectiveness of hypolipidemic treatment. It is concluded that thyroid function abnormalities are relatively common in dyslipidemic patients attending a lipid clinic and could significantly affect the patients' lipid profile as well as the patients' management.
Authors:
V Tsimihodimos; E Bairaktari; C Tzallas; G Miltiadus; E Liberopoulos; M Elisaf
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thyroid : official journal of the American Thyroid Association     Volume:  9     ISSN:  1050-7256     ISO Abbreviation:  Thyroid     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-06-17     Completed Date:  1999-06-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9104317     Medline TA:  Thyroid     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  365-8     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Medical School, University of Ioannina, Greece.
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MeSH Terms
Descriptor/Qualifier:
Dose-Response Relationship, Drug
Fasting
Female
Humans
Hyperlipidemias / blood,  diagnosis,  drug therapy,  etiology
Hypothyroidism / epidemiology
Incidence
Lipids / blood*
Male
Outpatients / statistics & numerical data*
Thyroid Diseases / complications,  epidemiology*
Thyrotropin / blood
Thyroxine / administration & dosage,  blood,  therapeutic use
Chemical
Reg. No./Substance:
0/Lipids; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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