Document Detail

The incidence of respiratory symptoms and sensitisation in baker apprentices.
MedLine Citation:
PMID:  18417513     Owner:  NLM     Status:  MEDLINE    
The aim of the current study was to describe the incidence of respiratory symptoms and allergic sensitisation and the sequence of events leading to respiratory symptoms among Danish baker apprentices (BA). A total of 114 BA were surveyed over a 20-month period. Questionnaires were completed along with spirometric analysis and skin-prick tests to common and work-related allergens. Bronchial hyperresponsiveness (BHR) was determined at baseline and at the end of the follow-up period. The incidences of work-related rhinitis and asthma-like symptoms were 22.1 and 10.0 cases.100 person-yrs(-1), respectively. At 20 months the cumulative incidence proportion was 40.2 and 20.5% for rhinitis and asthma-like symptoms, respectively. The cumulative incidence of occupational sensitisation was 6.1%. An increased risk of asthma-like symptoms was found in both atopic subjects and in females. In the BA with new onset respiratory symptoms, an increase in BHR from baseline was observed. Forced expiratory volume in one second and forced vital capacity did not change during the follow-up period. No relationship was observed between new sensitisation and new symptoms. In conclusion rhinitis- and asthma-like symptoms were found to develop commonly in Danish baker apprentices. The mechanism by which symptoms arose was perceived to reflect the development of an inflammation rather than the production of a specific immunoglobulin E pathway, as sensitisation to occupational allergens was rarely observed. Hence, respiratory symptoms and allergy may develop through separate pathways.
T Skjold; R Dahl; B Juhl; T Sigsgaard
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Publication Detail:
Type:  Journal Article     Date:  2008-04-16
Journal Detail:
Title:  The European respiratory journal     Volume:  32     ISSN:  1399-3003     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-01     Completed Date:  2008-11-18     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  452-9     Citation Subset:  IM    
Dept of Respiratory Medicine, Aarhus University Hospital, Noerrebrogade 44, 8000 Aarhus C, Denmark.
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MeSH Terms
Bronchial Hyperreactivity / diagnosis,  epidemiology*,  etiology*
Immunoglobulin E / chemistry
Lung Diseases / diagnosis,  epidemiology*,  etiology*
Occupational Diseases / diagnosis,  epidemiology*,  etiology*
Occupational Exposure*
Rhinitis / diagnosis,  epidemiology*,  etiology*
Time Factors
Reg. No./Substance:
37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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