Document Detail

The incidence of pulmonary non-tuberculous mycobacteria in British Columbia, Canada.
MedLine Citation:
PMID:  19723396     Owner:  NLM     Status:  MEDLINE    
SETTING: British Columbia Centre for Disease Control (BCCDC), Vancouver, Canada. OBJECTIVE: To determine the incidence of non-tuberculous mycobacteria (NTM) and to assess the impact of new laboratory techniques. DESIGN: Population-based study of all subjects with positive cultures for NTM from 1990 to 2006. RESULTS: Mycobacterium avium complex (MAC) was the most common NTM isolate (77%). The median incidence rates per 100 000 population in the total sample were respectively 6.7, 4.5 and <0.7 for all NTMs, MAC and all non-MAC species; for NTM-treated subjects the rates were respectively 1.6, 1.4 and <0.08; and for the NTM-colonised they were respectively 4.7, 2.7 and <0.5. In the period after the introduction of new laboratory techniques, all NTM isolates, the overall MAC rate and the MAC-colonised rate increased by respectively 24%, 35.4% and 76% (P < 0.05). All NTM isolates and rates for all NTMs, NTM-treated and M. tuberculosis subjects (used as comparison group) decreased over time (P < 0.05). CONCLUSION: The most common NTM species was MAC. Episodic increases in the number of isolates and incidence rates of subjects colonised with MAC are likely to be associated with the implementation of new laboratory techniques, which may represent an artefact. The decrease in rates of NTM-treated subjects is reassuring.
E Hernández-Garduño; M Rodrigues; R K Elwood
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease     Volume:  13     ISSN:  1815-7920     ISO Abbreviation:  Int. J. Tuberc. Lung Dis.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-09-02     Completed Date:  2009-12-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9706389     Medline TA:  Int J Tuberc Lung Dis     Country:  France    
Other Details:
Languages:  eng     Pagination:  1086-93     Citation Subset:  IM    
Department of TB Control, British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada.
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MeSH Terms
Bacteriological Techniques
British Columbia / epidemiology
Government Agencies
Mycobacteria, Atypical / isolation & purification*
Mycobacterium Infections, Atypical / diagnosis,  epidemiology*,  microbiology
Mycobacterium avium Complex / isolation & purification
Mycobacterium avium-intracellulare Infection / epidemiology
Predictive Value of Tests
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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