| The incidence and pathology of conjunctival ulceration in Behçet's syndrome. | |
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MedLine Citation:
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PMID: 11815335 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To describe the results of a study of the incidence of conjunctival ulceration and its pathology as a manifestation of Behçet's syndrome. METHODS: The authors reviewed retrospectively medical charts of 152 patients with Behçet's syndrome seen at the uveitis service of Okayama University Hospital from January 1995 to December 1999. Criteria used to diagnose Behçet's syndrome in this study required the presence of oral aphthous ulceration plus any two of three other manifestations-genital ulceration, eye lesions such as iridocyclitis and uveoretinitis, or skin lesions such as erythema nodosum. The presence of conjunctival ulceration was determined in patients with Behçet's syndrome through standardised ophthalmological examinations. A biopsy of the conjunctival ulceration was performed in one patient. The incidence of conjunctival ulceration in patients with Behçet's syndrome was calculated and the clinical and pathological features of this ulceration were examined. RESULTS: Four of 152 patients (2.6%) developed conjunctival ulceration in concordance with exacerbation of their systemic symptoms. Histopathological examinations of a conjunctival biopsy specimen in one patient revealed intraepithelial and perivascular infiltration with neutrophils and lymphocytes, consistent with Behçet's syndrome. The conjunctival ulcerations of the study patients showed good response to topical corticosteroids or topical steroids plus oral colchicine. CONCLUSIONS: Conjunctival ulceration should be noted as an uncommon but possible manifestation of Behçet's syndrome. Accordingly, routine examination of the conjunctiva is recommended in patients with Behçet's syndrome, and Behçet's syndrome should be included in a list of differential diagnoses for patients with conjunctival ulcerations. |
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Authors:
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Toshihiko Matsuo; Masako Itami; Hideki Nakagawa; Mikio Nagayama |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The British journal of ophthalmology Volume: 86 ISSN: 0007-1161 ISO Abbreviation: Br J Ophthalmol Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-01-29 Completed Date: 2002-03-07 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0421041 Medline TA: Br J Ophthalmol Country: England |
Other Details:
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Languages: eng Pagination: 140-3 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Okayama University Medical School, Okayama City, Japan. matsuot@cc.okayama-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Behcet Syndrome / pathology* Conjunctival Diseases / pathology* Diagnosis, Differential Female Humans Male Middle Aged Retrospective Studies Ulcer / pathology* |
| Comments/Corrections | |
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