Document Detail

Is the incidence of deep vein thrombosis following myocardial infarction decreasing?
MedLine Citation:
PMID:  6930207     Owner:  NLM     Status:  MEDLINE    
A trial was undertaken to compare the effectiveness of the antiplatelet drug, flurbiprofen, and subcutaneous heparin in the prevention of deep vein thrombosis following acute myocardial infarction. The original aim of the study could not be fulfilled as the incidence of isotopically-determined venous thrombosis in the group of control patients was only 9.5%. The incidence in all three groups was too low to assess the effectiveness of flurbiprofen prophylaxis. It is suggested that the low incidence may be related to the recent practice of early physiotherapy and ambulation in coronary care units. The patients who developed venous thrombosis were, on average, a little older than those who did not. No differences were observed in blood viscosity, plasma antithrombin III concentration or mean coronary prognostic index. The low incidence of venous thrombosis following acute myocardial infarction suggests a need to reassess the practice of prophylactic anticoagulant therapy in this condition.
W R Pitney; A Hickey; A Gopinath; S Dean
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Australian and New Zealand journal of medicine     Volume:  10     ISSN:  0004-8291     ISO Abbreviation:  Aust N Z J Med     Publication Date:  1980 Apr 
Date Detail:
Created Date:  1980-08-28     Completed Date:  1980-08-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1264322     Medline TA:  Aust N Z J Med     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  167-71     Citation Subset:  IM    
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MeSH Terms
Antithrombin III / metabolism
Blood Viscosity
Flurbiprofen / therapeutic use*
Heparin / administration & dosage,  therapeutic use*
Injections, Subcutaneous
Middle Aged
Myocardial Infarction / complications*
Propionates / therapeutic use*
Thrombophlebitis / blood,  prevention & control*
Reg. No./Substance:
0/Propionates; 5104-49-4/Flurbiprofen; 9000-94-6/Antithrombin III; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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