Document Detail

The incidence and clinical predictors of early stent thrombosis in patients with acute coronary syndrome.
MedLine Citation:
PMID:  20102877     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Acute coronary syndrome (ACS) is associated with activation of platelets and the coagulation system which could influence the incidence of early stent thrombosis (EST). We aimed to determine the incidence and predictors of EST in patients undergoing coronary stenting during ACS. METHODS: The study comprised 1202 consecutive patients, drawn from a nationwide ACS survey, who underwent coronary stenting during ACS and were followed up for 30 days. Early stent thrombosis was based on the Academic Research Consortium definition. RESULTS: Thirty patients (2.5%) sustained EST. The occurrence of EST in patients with unstable angina/non-ST-elevation myocardial infarction and ST-elevation myocardial infarction (STEMI) was 0.9% and 3.9%, respectively (P < .05), and was even higher (5.2%) in STEMI patients who underwent primary percutaneous coronary intervention. On multivariate analysis, STEMI (OR 6.3, 95% CI 2.1-18, P = .0008), multivessel disease (OR 5.9, 95% CI 1.9-21, P = .003) and Killip class >/=2 (OR 2.9, 95% CI 1.3-6.6, P = .008) were independent correlates of EST. The use of bare versus drug-eluting stents was not associated with any significant difference in EST. CONCLUSIONS: Patients presenting with STEMI who are hemodynamically unstable and have multivessel coronary disease undergoing coronary stenting during ACS, are at increased risk of EST.
Roy Beinart; Raed Abu Sham'a; Amit Segev; Hanoch Hod; Victor Guetta; Michael Shechter; Valentina Boyko; Shlomo Behar; Shlomi Matetzky
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  159     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-27     Completed Date:  2010-03-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  118-24     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2010 Mosby, Inc. All rights reserved.
Heart Institute, Sheba Medical Center, Tel Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
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MeSH Terms
Acute Coronary Syndrome / diagnosis,  mortality,  therapy*
Age Factors
Angioplasty, Transluminal, Percutaneous Coronary / adverse effects*,  methods
Cohort Studies
Confidence Intervals
Coronary Restenosis / epidemiology,  etiology,  physiopathology
Drug-Eluting Stents
Middle Aged
Multivariate Analysis
Odds Ratio
Predictive Value of Tests
Prosthesis Failure*
Retrospective Studies
Risk Assessment
Sex Factors
Survival Rate
Thrombosis / epidemiology*,  etiology,  physiopathology
Time Factors

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