Document Detail


The incidence and clinical correlates of lithium toxicity: a retrospective review.
MedLine Citation:
PMID:  21516355     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Lithium is a commonly prescribed pharmacological treatment for mood disorders. It is associated with a number of side effects and potentially serious toxicity. To date, there is little data from Irish samples on the subject of Lithium toxicity. AIM: To examine the incidence and clinical correlates of lithium toxicity in Cork, Ireland. RESULTS: Our study identified 130 cases of biochemical lithium toxicity over 5 years, with an incidence rate of approximately 5.4 cases per 100,000 per year. Mean toxic lithium level was 2.16 mmol/L ±SD 0.87 mmol/L. Of these, 36% cases were reviewed medically in the general hospital at the time of toxicity. A number of issues in relation to lithium toxicity were identified. Neurological symptoms were common, including tremor, confusion, ataxia, drowsiness. However, only 4.2% patients were reviewed by a neurologist while in hospital. Medications that interact with lithium were found in 50% cases, with significant polypharmacy in 15%. The psychiatric services were involved in patient care in 76% cases, and 85% patients presenting with toxicity were reviewed by a psychiatrist. Rates of admission to hospital and haemodialysis were 70 and 11%, respectively. CONCLUSION: Improvements in the standards of care in relation to lithium prescribing are required.
Authors:
U Dennison; M Clarkson; J O'Mullane; E M Cassidy
Related Documents :
17850635 - Auditory pathology in cri-du-chat (5p-) syndrome: phenotypic evidence for auditory neur...
9286025 - Prenatal diagnosis of ectopia cordis at 10 weeks of gestation using two-dimensional and...
9354845 - Anencephaly with holoprosencephalic facies due to ring chromosome 18.
6770635 - Fetal ascites not associated with rh incompatibility: recognition and management with s...
24820945 - Some considerations of the tolerability of ketamine for ect anesthesia: a case series a...
19803275 - Lipoblastoma of the back; a case of a 7-month-old boy.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-23
Journal Detail:
Title:  Irish journal of medical science     Volume:  -     ISSN:  1863-4362     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806864     Medline TA:  Ir J Med Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Psychiatry, Cork University Hospital, Cork, Ireland, una.dennison@hse.ie.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Genetics and molecular mapping of genes for high-temperature resistance to stripe rust in wheat cult...
Next Document:  Post-traumatic stress disorder, depression, and health-related quality of life in OEF/OIF veterans.