| The incidence and characteristics of uterine bleeding during postoperative GnRH agonist treatment combined with tibolone add-back therapy in endometriosis patients of reproductive age. | |
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MedLine Citation:
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PMID: 16806656 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: This study was undertaken to evaluate the incidence and the factors associated with uterine bleeding while taking GnRH agonist treatment combined with tibolone add-back therapy in endometriosis patients of reproductive age. STUDY DESIGN: The medical records of 188 endometriosis (stages III-IV) patients of reproductive age receiving postoperative GnRH agonist treatment combined with tibolone add-back therapy for 6 months were reviewed. Clinical features were analyzed and compared between the two groups: Group A, patients without an episode of uterine bleeding (n=137) and Group B, patients that had experienced uterine bleeding (n=51). RESULTS: Demographic profiles were not different in the two groups. The incidence of uterine bleeding was 27.1% and irregular spotting was the most frequent bleeding pattern. The proportion of patients who received ovarian surgery during pelviscopy was higher in Group B (p<0.05), but other clinical characteristics were not different between two groups. CONCLUSIONS: The incidence of uterine bleeding was 27.1%. And, the proportion of patients who received ovarian surgery was higher in patients with uterine bleeding. |
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Authors:
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So-Young Shin; Jung-Ae Min; Byung-Koo Yoon; Duk Soo Bae; Doo Seok Choi |
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Publication Detail:
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Type: Journal Article Date: 2006-06-27 |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 133 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-06-26 Completed Date: 2007-09-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
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Languages: eng Pagination: 90-4 Citation Subset: IM |
Affiliation:
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Department of Obstetrics & Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-Dong Gangnam-gu, Seoul, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Drug Therapy, Combination Endometriosis / drug therapy*, surgery Female Gonadotropin-Releasing Hormone / agonists* Humans Incidence Norpregnenes / therapeutic use* Postoperative Complications / epidemiology*, ultrasonography Retrospective Studies Uterine Hemorrhage / epidemiology*, ultrasonography |
| Chemical | |
Reg. No./Substance:
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0/Norpregnenes; 33515-09-2/Gonadotropin-Releasing Hormone; 5630-53-5/tibolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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