| The incidence of Proteus mirabilis infection increases in patients on treatment but does not trigger disease activity. | |
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MedLine Citation:
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PMID: 16267598 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study is to determine whether treatment increases the levels of anti-Proteus antibodies (APA) in patients with rheumatoid arthritis (RA). The blood samples of 32 patients suffering from RA who were recruited in our previous study and continued to participate in our follow-up study were collected after 1 year. Their first and follow-up samples were analysed for the presence of IgG isotype and total immunoglobulins (IgG+IgA+IgM) against Proteus mirabalis (PM) using enzyme-linked immunosorbent assay with two kinds of antigen preparations: whole bacteria and sodium dodecyl sulphate (SDS) lysed bacterial extract. All patients were treated with methotrexate and hydroxychloroquine with adequate dose of non-steroidal anti-inflammatory drug. After 1 year, 11 patients were in clinical remission [erythrocyte sedimentation rate (ESR) less than 30 mm/h and C-reactive protein (CRP) less than or equal to 10 mg/l], while the rest of the 21 were in the state of active disease. Correlation and Student's t test were used for statistical analysis. APA titres were significantly elevated in patients after 1 year of therapy. However, the rise was not different between patients who were in clinical remission and those in the state of active disease. APA titre increases in the treatment of RA, and the probable mechanisms are discussed. |
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Authors:
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S Chandrashekara; Rajreddy Patil; H S Vadiraja; A Shobha |
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Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2005-11-03 |
Journal Detail:
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Title: Clinical rheumatology Volume: 25 ISSN: 0770-3198 ISO Abbreviation: Clin. Rheumatol. Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-07-27 Completed Date: 2006-11-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8211469 Medline TA: Clin Rheumatol Country: Belgium |
Other Details:
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Languages: eng Pagination: 520-3 Citation Subset: IM |
Affiliation:
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Department of Clinical Immunology, M.S Ramaiah Medical College, 560054, Bangalore, India. chandrashekara_s@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Inflammatory Agents, Non-Steroidal / therapeutic use* Antibodies, Bacterial / blood* Antibody Specificity Antirheumatic Agents / therapeutic use* Arthritis, Rheumatoid / complications*, drug therapy Female Folic Acid / therapeutic use Follow-Up Studies Humans Hydroxychloroquine / therapeutic use Immunoglobulins / blood Male Methotrexate / therapeutic use Middle Aged Proteus Infections / blood, complications*, immunology Proteus mirabilis / immunology Remission Induction Serologic Tests Steroids / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antibodies, Bacterial; 0/Antirheumatic Agents; 0/Immunoglobulins; 0/Steroids; 118-42-3/Hydroxychloroquine; 59-05-2/Methotrexate; 59-30-3/Folic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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