| The inactivation of rat adipocyte Mg2+-dependent phosphatidate phosphohydrolase by noradrenaline. | |
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MedLine Citation:
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PMID: 6258575 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The inactivation of rat adipocyte Mg2+-dependent phosphatidate phosphohydrolase by noradrenaline [Cheng & Saggerson (1978) FEBS Lett. 87, 65--68; Cheng & Saggerson (1978) FEBS Lett. 93, 120--124] persists for at least 40 min in crude defatted homogenates kept at 0 degrees C or 20 degrees C, but is diminished at 37 degrees C. The effect of noradrenaline persists through the isolation of post-105000 g supernatants and is then stable in these preparations at 0 degrees C and 37 degrees C. Inclusion of albumin (10--20 mg/ml) in homogenization buffers abolishes the effect of noradrenaline. The effect of noradrenaline is not removed by dialysis of extracts or by raising the concentrations of Mg2+ or phosphatidate in assays. |
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Authors:
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C H Cheng; E D Saggerson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Biochemical journal Volume: 190 ISSN: 0264-6021 ISO Abbreviation: Biochem. J. Publication Date: 1980 Sep |
Date Detail:
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Created Date: 1981-04-21 Completed Date: 1981-04-21 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2984726R Medline TA: Biochem J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 659-62 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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cytology,
drug effects,
enzymology* Albumins / pharmacology Animals Centrifugation Magnesium / pharmacology Norepinephrine / pharmacology* Phosphatidate Phosphatase / antagonists & inhibitors* Phosphatidic Acids / metabolism Phosphoric Monoester Hydrolases / antagonists & inhibitors* Rats Temperature |
| Chemical | |
Reg. No./Substance:
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0/Albumins; 0/Phosphatidic Acids; 51-41-2/Norepinephrine; 7439-95-4/Magnesium; EC 3.1.3.-/Phosphoric Monoester Hydrolases; EC 3.1.3.4/Phosphatidate Phosphatase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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