Document Detail

An in vivo study of the plaque control efficacy of Persica: a commercially available herbal mouthwash containing extracts of Salvadora persica.
MedLine Citation:
PMID:  15503853     Owner:  NLM     Status:  MEDLINE    
AIM: This study compared the oral health efficacy of Persica mouthwash (containing an extract of Salvadora persica) with that of a placebo. DESIGN: In a double-blind, cross-over trial, participants were randomly allocated to use either the Persica mouthwash or a placebo for a three-week period. Plaque accumulation, gingival bleeding and the salivary concentrations of mutans streptococci (MS) were measured before and immediately following the experimental period. After an eight-week 'washout' period, the study was repeated with participants using the alternative mouthwash. PARTICIPANTS: Twenty-eight healthy students (aged between 18 and 42 years) volunteered to take part in this investigation. RESULTS: Compared with the pre-treatment values, both placebo and experimental groups demonstrated significantly reduced gingival bleeding (p < 0.01). Plaque scores were not significantly reduced following use of either Persica or the placebo. However, the use of Persica, but not the placebo, resulted in significant reduction in the carriage of MS (p < 0.05). CONCLUSION: Use of Persica mouthwash resulted in improved gingival health and lower carriage rate of cariogenic bacteria when compared with the pre-treatment values. The placebo (vehicle control) also improved gingival health significantly. Neither the Persica nor the placebo reduced the accumulation of dental plaque.
A M Khalessi; A R C Pack; W M Thomson; G R Tompkins
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  International dental journal     Volume:  54     ISSN:  0020-6539     ISO Abbreviation:  Int Dent J     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-26     Completed Date:  2004-11-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374714     Medline TA:  Int Dent J     Country:  England    
Other Details:
Languages:  eng     Pagination:  279-83     Citation Subset:  D; IM    
Department of Oral Sciences and Orthodontics, University of Otago, Dunedin, New Zealand.
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MeSH Terms
Colony Count, Microbial
Cross-Over Studies
Dental Plaque / prevention & control*
Double-Blind Method
Gingivitis / prevention & control*
Mouthwashes / pharmacology,  therapeutic use*
Multivariate Analysis
Periodontal Index
Pilot Projects
Plant Extracts / pharmacology,  therapeutic use*
Saliva / microbiology
Streptococcus mutans / drug effects,  isolation & purification
Reg. No./Substance:
0/Mouthwashes; 0/Plant Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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