Document Detail


An in vivo study of the microlymphatics in psoriasis using fluorescence microlymphography.
MedLine Citation:
PMID:  10215769     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Angiogenesis is a recognized event in psoriasis. Previous ultrastructural studies have demonstrated lymphatic capillaries extending high into the dermal papillae. Using the novel method of fluorescence microlymphography which permits visualization of upper dermal initial lymphatics in vivo we tested the hypothesis that lymphangiogenesis exists within plaque psoriasis. Six patients underwent fluorescence microlymphography with fluorescein isothiocyanate-dextran administered intracutaneously within a psoriatic plaque on the leg. Stereological analysis permitted quantification of the lymphatic network opacified both within (lesional) and without (perilesional) the plaque. Results showed a greater spread of tracer from the depot into perilesional skin than into the plaque (P < 0.006). The mean length of lymphatics per unit area at increasing distance from the centre of the depot was also increased for the perilesional skin, 10.5 +/- 1.9/cm2 (mean +/- SEM), compared with lesional skin, 3.06 +/- 0.8/cm (P < 0.001). The cumulative lymphatic length was also greater in perilesional, 22 +/- 7.3 cm2, compared with lesional skin, 3.6 +/- 0.3 cm (P < 0.006). Fluorescence microlymphography has proved to be an effective in vivo technique for the assessment of the dermal microlymphatics in psoriasis. Stereology provided quantitative analysis of the lymphatic network visualized. Overall, there is a greater network of lymphatics in perilesional compared with lesional skin in patients with plaque psoriasis. This finding is at odds with the accepted view that the lymphatic dermal vessels are increased within the psoriatic plaque.
Authors:
S Cliff; A J Bedlow; A W Stanton; P S Mortimer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of dermatology     Volume:  140     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  2000-03-17     Completed Date:  2000-03-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  61-6     Citation Subset:  IM    
Affiliation:
Department of Medicine, Division of Physiological Medicine (Dermatology), St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, U.K.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Capillaries / pathology,  radiography
Female
Fluorescein-5-isothiocyanate / diagnostic use
Humans
Lymphatic Diseases / pathology*
Lymphatic System / blood supply
Lymphography / methods
Male
Microchemistry
Middle Aged
Psoriasis / pathology*,  radiography
Chemical
Reg. No./Substance:
3326-32-7/Fluorescein-5-isothiocyanate
Comments/Corrections
Erratum In:
Br J Dermatol 1999 Aug;141(2):392

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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