Document Detail

The in vivo genotoxic effects of sodium metabisulphite in bone marrow cells of rats.
MedLine Citation:
PMID:  17958310     Owner:  NLM     Status:  MEDLINE    
This study is designed to investigate the genotoxic effect of sodium metabisulphite (SMB), which is used as an antimicrobial substance in foods on bone marrow cells of rats. Four different concentrations of SMB (250, 500, 750 and 1000 mg/kg body weight) were given rats (Rattus norvegicus var. albinos) for 6, 12 and 24 hours treatment period by intraperitoneal (IP) and gavage (GV) administrations. In this study, we found that intraperitoneal implement of SMB generally more effective increasing the percentage of abnormal cells and CA/cell in all concentrations and treatment period. In addition, mitotic index (MI) data of intraperitoneal injection are lower than gavage. It can be concluded that potential genotoxic effects of SMB by IP injection is higher than GV injection.
A Kayraldiz; M Topaktaş
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genetika     Volume:  43     ISSN:  0016-6758     ISO Abbreviation:  Genetika     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-10-25     Completed Date:  2007-11-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0047354     Medline TA:  Genetika     Country:  Russia (Federation)    
Other Details:
Languages:  eng     Pagination:  1091-6     Citation Subset:  IM    
Biology Department, Faculty of Arts and Sciences, University of Kahramanmaraş Sütçü Imam, Turkey.
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MeSH Terms
Administration, Oral
Bone Marrow Cells / drug effects*
Injections, Intraperitoneal
Mutagenicity Tests
Rats, Inbred Strains
Sulfites / administration & dosage,  toxicity*
Reg. No./Substance:
0/Sulfites; 7681-57-4/sodium metabisulfite

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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