| The in vivo diagnosis of early-stage aortic valve sclerosis using magnetic resonance imaging in a rabbit model. | |
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MedLine Citation:
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PMID: 19306405 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To use magnetic resonance imaging (MRI) to identify and monitor early aortic valve sclerosis (AVS) induced by cholesterol feeding in rabbits. AVS is a highly prevalent disease process, affecting more than 25% of the population over age 65. A major obstacle to early stage medical management of AVS has been the lack of an objective noninvasive technique to identify its presence and monitor its progress. MATERIALS AND METHODS: Retrospectively gated CINE fast spoiled gradient echo (fSPGR) images of aortic valve cusps were collected at 3-month intervals starting at 6 months using a 1.5 T MR scanner interfaced with a customized surface radiofrequency coil. At 16 months a subset of animals was sacrificed and excised cusps were examined with both high frequency ultrasound (US) and histopathological techniques to validate the MRI method. RESULTS: MR and US analysis identified significant thickening of diseased AV cusps when compared to control (P < 0.05). Histopathological analysis confirmed the presence of human-like AVS in diseased rabbit valves. CONCLUSION: Early AVS, exemplified by increased valve thickness, can be identified in vivo using high-resolution MRI. |
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Authors:
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Amanda M Hamilton; Kem A Rogers; Maria Drangova; Zamir Khan; John A Ronald; Brian K Rutt; Kyle A Maclean; James C Lacefield; Derek R Boughner |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 29 ISSN: 1053-1807 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-03-26 Completed Date: 2009-05-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 825-31 Citation Subset: IM |
Affiliation:
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Department of Anatomy & Cell Biology, The University of Western Ontario, London, ON, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Aortic Diseases / diagnosis* Atherosclerosis / diagnosis* Cholesterol / metabolism* Cholesterol, Dietary / metabolism* Hypercholesterolemia / diagnosis* Image Processing, Computer-Assisted Magnetic Resonance Imaging, Cine / methods* Male Rabbits Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, Dietary; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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