| The in vitro and in vivo cytotoxicity of menadione (vitamin K3) against rat transplantable hepatoma induced by 3'-methyl-4-dimethyl-aminoazobenzene. | |
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MedLine Citation:
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PMID: 1779438 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Menadione (vitamin K3, 2-methyl-1,4-naphthoquinone) is a synthetic derivative of napthoquinone. Its ability to inhibit cell growth in a wide variety of and human tumor cell types, and in rat hepatocytes has been recognized. Using a rat transplantable hepatoma model, we have evaluated the cytotoxic activity of menadione in hepatoma cells. Tumor cells in culture were sensitive to menadione treatment. The ID50 of drug is 3.4 microM as shown by a colorimetric MTT (3-(4,5-dimethythiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Tumor-bearing rats were randomized into the treatment (n = 16) and control (n = 15) groups. Rats in the treatment group received intraperitoneal injection of menadione (10 mg/2 ml) once a week for four times; the control group received 2 ml water instead. None of the control rats survived after the 17th day following the start of treatment, while 5 out of the 16 treated rats responded well and survived long-term (greater than 60 days). Medadione was shown to inhibit actively the growth of hepatoma cells in vitro as well as in vivo. |
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Authors:
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W C Su; T P Sun; F Y Wu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Gaoxiong yi xue ke xue za zhi = The Kaohsiung journal of medical sciences Volume: 7 ISSN: 0257-5655 ISO Abbreviation: Gaoxiong Yi Xue Ke Xue Za Zhi Publication Date: 1991 Sep |
Date Detail:
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Created Date: 1992-03-12 Completed Date: 1992-03-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8603880 Medline TA: Gaoxiong Yi Xue Ke Xue Za Zhi Country: TAIWAN |
Other Details:
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Languages: eng Pagination: 454-9 Citation Subset: D; IM |
Affiliation:
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Department of Internal Medicine, National Cheng-Kung University Hospital, Taiwan, Republic of China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Liver Neoplasms, Experimental / chemically induced, drug therapy* Male Methyldimethylaminoazobenzene Neoplasm Transplantation Rats Rats, Inbred Strains Tumor Cells, Cultured / drug effects Vitamin K / pharmacology*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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12001-79-5/Vitamin K; 55-80-1/Methyldimethylaminoazobenzene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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