Document Detail


The in vitro survival of human monosomies and trisomies as embryonic stem cells.
MedLine Citation:
PMID:  22892439     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Chromosomal aneuploidies are responsible for severe human genetic diseases. Aiming at creating models for such disorders, we have generated human embryonic stem cell (hESC) lines from pre-implantation genetic screened (PGS) embryos. The overall analysis of more than 400 aneuploid PGS embryos showed a similar risk of occurrence of monosomy or trisomy for any specific chromosome. However, the generation of hESCs from these embryos revealed a clear bias against monosomies in autosomes. Moreover, only specific trisomies showed a high chance of survival as hESC lines, enabling us to present another categorization of human aneuploidies. Our data suggest that chromosomal haploinsufficiency leads to lethality at very early stages of human development.
Authors:
Juan Carlos Biancotti; Kavita Narwani; Berhan Mandefro; Tamar Golan-Lev; Nicole Buehler; David Hill; Clive N Svendsen; Nissim Benvenisty
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-22
Journal Detail:
Title:  Stem cell research     Volume:  9     ISSN:  1876-7753     ISO Abbreviation:  Stem Cell Res     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-8-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101316957     Medline TA:  Stem Cell Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  218-224     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Affiliation:
Regenerative Medicine Institute and Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
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