Document Detail

An in vitro study of the effects of exposure to a GSM signal in two human cell lines: monocytic U937 and neuroblastoma SK-N-SH.
MedLine Citation:
PMID:  16877012     Owner:  NLM     Status:  MEDLINE    
The use of mobile phones is increasing, which also increases the population's exposure to global system of mobile communications (GSM) signals. Questions of safety and possible biological effects are of concern and to date, remain largely unanswered. In order to examine possible biological effects of a GSM-like signal at a cellular level, we exposed two human cell lines (one of neuronal (SK-N-SH) and the other of monocytoid (U937) origin) to a 900 MHz RF signal, pulsed at 217 Hz, producing a specific absorption rate (SAR) of 0.2 W/kg. Putative effects were assessed by comparing radiofrequency-exposed cells to sham-exposed cells using a variety of assay techniques. For the cell line SK-N-SH, effects were specifically assessed by gene microarray, followed by real-time PCR of the genes of interest, Western blot analysis was used to measure heat shock protein levels, and flow cytometry to measure cell cycle distributions and apoptosis. Effects of radiofrequency on the cell line U937 were assessed by cell viability and cell cycle analysis. From our study of these two cell lines, we found no significant difference between sham-exposed versus radiofrequency-exposed cells in any of the assays or conditions examined.
Ebru Gurisik; Kristina Warton; Donald K Martin; Stella M Valenzuela
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-06-30
Journal Detail:
Title:  Cell biology international     Volume:  30     ISSN:  1065-6995     ISO Abbreviation:  Cell Biol. Int.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-23     Completed Date:  2007-01-31     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9307129     Medline TA:  Cell Biol Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  793-9     Citation Subset:  IM    
Department of Health Sciences, University of Technology Sydney, Sydney, NSW, Australia.
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MeSH Terms
Apoptosis / radiation effects
Cell Cycle / radiation effects
Cell Line
Cell Physiological Phenomena / radiation effects*
Cell Survival / radiation effects
Cellular Phone
Electromagnetic Fields / adverse effects*
Gene Expression / radiation effects
Heat-Shock Proteins / analysis
Radio Waves / adverse effects
Tumor Cells, Cultured
U937 Cells
Reg. No./Substance:
0/Heat-Shock Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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