| An in vitro study on the active conversion of flucytosine to fluorouracil by microorganisms in the human intestinal microflora. | |
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MedLine Citation:
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PMID: 12714804 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Investigation of the rate of active conversion of flucytosine to fluorouracil by microorganisms in the intestinal microflora. METHODS: Active conversion of flucytosine was investigated using viable and nonviable Escherichia coli at different flucytosine concentrations. Additionally, flucytosine conversion was studied in fecal specimens from 3 neutropenic patients at the start of the antimicrobial/antifungal prophylaxis (C/A regimen) and 1 week later. RESULTS: Flucytosine levels decreased by an average of 72, 71 and 72% flucytosine after incubation for 48 h of 10(10) viable E. coli /ml suspension in broth containing 13, 130 and 1300 mg/l flucytosine, respectively. The decreasing flucytosine levels corresponded approximately to an identical increase in fluorouracil levels. Also, a 44% decrease of flucytosine levels occurred when nonviable E. coli were used, indicating that bacterial viability is not necessary for this conversion. When fecal specimens of 2 patients were investigated prior to the C/A regimen, significant flucytosine conversion occurred, whereas this conversion was not observed in the corresponding fecal specimens after 1 week of C/A regimen. CONCLUSION: These in vitro experiments showed that extensive flucytosine conversion can occur in the human intestinal microflora by E. coli. Consequently, fluorouracil exposure and fluorouracil-related toxicity may occur in the flucytosine-treated patient. |
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Authors:
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András Vermes; Ed J Kuijper; Henk-Jan Guchelaar; Jacob Dankert |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Chemotherapy Volume: 49 ISSN: 0009-3157 ISO Abbreviation: Chemotherapy Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-04-25 Completed Date: 2003-12-08 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0144731 Medline TA: Chemotherapy Country: Switzerland |
Other Details:
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Languages: eng Pagination: 17-23 Citation Subset: IM |
Copyright Information:
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Copyright 2003 S. Karger AG, Basel |
Affiliation:
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Department of Clinical Pharmacy, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. a.vermes@erasmusmc.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antifungal Agents
/
adverse effects,
metabolism* Child Dose-Response Relationship, Drug Escherichia coli / drug effects, metabolism* Feces / microbiology Female Flucytosine / adverse effects, metabolism* Fluorouracil / adverse effects, metabolism* Humans Intestines / microbiology* Male Middle Aged Neutropenia / chemically induced |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 2022-85-7/Flucytosine; 51-21-8/Fluorouracil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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