Document Detail


An in vitro study on mefloquine/quinine in Plasmodium falciparum malaria.
MedLine Citation:
PMID:  1744537     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An in vitro designed for determining sensitivity of Plasmodium falciparum strains isolated from Kanchanaburi Province, to Mefloquine/Quinine combination, was carried out. The MIC values of Mefloquine/Quinine for the P.falciparum strains were found to be 0.075/3.75 to 0.225/11.15 nM/ml. The changes observed following the drug treatment were an enlargement of the space between the outer and the inner limiting membrane of the parasitophorous vacuole. These changes were followed by cytoplasmic degeneration and vacuolation.
Authors:
P Jariya; S Tiewchaloren; K Mankalanond
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the Medical Association of Thailand = Chotmaihet thangphaet     Volume:  74     ISSN:  0125-2208     ISO Abbreviation:  J Med Assoc Thai     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1992-01-14     Completed Date:  1992-01-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7507216     Medline TA:  J Med Assoc Thai     Country:  THAILAND    
Other Details:
Languages:  eng     Pagination:  327-30     Citation Subset:  IM    
Affiliation:
Department of Parasitology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
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MeSH Terms
Descriptor/Qualifier:
Animals
Drug Combinations
Drug Evaluation, Preclinical
Humans
Mefloquine / pharmacology*
Plasmodium falciparum / drug effects*,  growth & development,  ultrastructure
Quinine / pharmacology*
Chemical
Reg. No./Substance:
0/Drug Combinations; 130-95-0/Quinine; 53230-10-7/Mefloquine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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