Document Detail


An in vitro model for monitoring bacterial responses to antibiotic agents under simulated in vivo conditions.
MedLine Citation:
PMID:  6772578     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new in vitro model for the study of bacterial responses to antibacterial agents at exponentially varying concentrations, i. e. at given elimination half-life values simulating in vivo conditions, is described. The initial concentrations and elimination rates of the agents, composition of bacterial milieu, and commencing density of the bacterial population may be altered. The principal responses of key gram-negative and gram-positive species to bactericidal and bacteriostatic agents and experimental variation are described.
Authors:
T Bergan; I B Carlsen; J E Fuglesang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Infection     Volume:  Suppl 1     ISSN:  0300-8126     ISO Abbreviation:  Infection     Publication Date:  1980  
Date Detail:
Created Date:  1980-10-27     Completed Date:  1980-10-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0365307     Medline TA:  Infection     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  096-10     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / pharmacology*
Carbenicillin / pharmacology
Cefazolin / pharmacology
Chloramphenicol / pharmacology
Escherichia coli / drug effects
Humans
Microbial Sensitivity Tests*
Models, Biological*
Oxytetracycline / pharmacology
Pseudomonas aeruginosa / drug effects
Staphylococcus aureus / drug effects
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 25953-19-9/Cefazolin; 4697-36-3/Carbenicillin; 56-75-7/Chloramphenicol; 79-57-2/Oxytetracycline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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