Document Detail


An in vitro fluid dynamic study of pediatric cannulae: the value of animal studies to predict human flow.
MedLine Citation:
PMID:  22667684     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A challenge to the development of pediatric ventricular assist devices (PVADs) is the use of the aortic cannulae attached to the devices. Cannulae used for pediatric application have small diameters and large pressure drops. Furthermore, during the development of the 12cc Penn State pediatric PVAD, particle image velocimetry (PIV) illustrated that hematocrit levels, through changes in blood viscoelasticity, affected the fluid dynamics. The objective of this study is to compare the fluid dynamics of a pediatric viscoelastic blood analog and a goat viscoelastic blood analog within the PVAD aortic cannula. Two acrylic models were manufactured to model the aortic cannula (6 mm and 8 mm diameters). PIV data was collected to examine the flow at the outlet of the VAD and in the aortic cannula at heart rates of 50 and 75 beats per minute (bpm). Three planes of data were taken, one at the centerline and two 1.5 mm above and below the centerline. Three more planes of data were taken orthogonal to the original planes. While a 75 bpm heart rate was used to represent normal operating conditions, a 50 bpm heart rate represented use of the PVAD during weaning. At 75 bpm, differences were evident between the two different fluids and the two models. Separation zones developed in the plane below the centerline for the higher hematocrit pediatric blood analog. This study raises question to the usefulness of animal testing results in regard to how well they predict the outcome of pediatric patients.
Authors:
Tobias C Long; Joseph J Pearson; Andrew C Hankinson; Steven Deutsch; Keefe B Manning
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomechanical engineering     Volume:  134     ISSN:  1528-8951     ISO Abbreviation:  J Biomech Eng     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-06-06     Completed Date:  2012-12-21     Revised Date:  2013-08-14    
Medline Journal Info:
Nlm Unique ID:  7909584     Medline TA:  J Biomech Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  044501     Citation Subset:  IM    
Affiliation:
Department of Bioengineering, The Pennsylvania State University, University Park, PA 16802, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure
Catheters*
Child
Goats
Heart Rate
Heart-Assist Devices*
Hematocrit
Humans
Hydrodynamics*
Rheology
Grant Support
ID/Acronym/Agency:
HV 48191/HV/NHLBI NIH HHS
Comments/Corrections

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