| An in vitro, ex vivo, and in vivo demonstration of the lipolytic effect of slimming liposomes: An unexpected alpha(2)-adrenergic antagonism. | |
| | |
MedLine Citation:
|
PMID: 12219247 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Most of the slimming products already developed for cosmetic applications did not result from strategies that integrate whole lipolysis-regulating mechanisms. We thus focused our attention on a more complete integration of these mechanisms and we developed slimming liposomes (SLC) containing two micro-circulation activators, i.e., esculoside and Centella asiatica extracts, one phosphodiesterase inhibitor, i.e., caffeine, and one fatty acid-beta oxidation activator, i.e., L-carnitine. The validity of our approach was assessed through (a) in vitro tests demonstrating that SLC induced a dramatic increase in the cyclic adenosine monophosphate (cAMP) content in human adipocytes, with a subsequent rise in the nonesterified fatty acids (NEFA) content of human adipocyte incubation medium, and (b) in vivo studies showing that SLC could provide an actual potent slimming effect on human volunteers. Moreover, we give here, through binding experiments, the unambiguous demonstration that SLC is able to antagonize the alpha(2)-adrenergic receptor that is known to reduce intracellular AMPc content and, subsequently, to down-regulate lipolysis. This alpha(2)-adrenergic antagonism has never been reported for any component of SLC, and this work is the first demonstration of the alpha(2)-adrenergic antagonism of such a combination of active liposome compounds. |
| | |
Authors:
|
L Tholon; G Neliat; C Chesne; D Saboureau; E Perrier; J-E Branka |
Related Documents
:
|
20039617 - Synthesis of alpha,omega-diarylbutadienes and -hexatrienes via decarboxylative coupling... 512407 - Multiple forms and glycoprotein nature of acid phosphatase, alpha-fucosidase and alpha-... 6870847 - Novel mannose carrier in the trypanosomatid crithidia fasciculata behaving as a short a... 8217467 - Carbohydrate histochemistry of skin glands in the turkish angora goat. 1825117 - 4-(tetrazolylalkyl)piperidine-2-carboxylic acids. potent and selective n-methyl-d-aspar... 9698227 - High-performance liquid chromatographic determination of beta-alanine, beta-aminoisobut... |
Publication Detail:
|
Type: Clinical Trial; Controlled Clinical Trial; In Vitro; Journal Article |
Journal Detail:
|
Title: Journal of cosmetic science Volume: 53 ISSN: 1525-7886 ISO Abbreviation: J Cosmet Sci Publication Date: 2002 Jul-Aug |
Date Detail:
|
Created Date: 2002-09-09 Completed Date: 2002-10-08 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9814276 Medline TA: J Cosmet Sci Country: United States |
Other Details:
|
Languages: eng Pagination: 209-18 Citation Subset: IM |
Affiliation:
|
Coletica, 32 rue Saint Jean de Dieu, 69007 Lyon, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adipocytes
/
drug effects,
metabolism Adrenergic alpha-Antagonists / pharmacology Cyclic AMP / metabolism Lipolysis* Liposomes* Receptors, Adrenergic, alpha-2 / antagonists & inhibitors* Weight Loss / drug effects* |
| Chemical | |
Reg. No./Substance:
|
0/Adrenergic alpha-Antagonists; 0/Liposomes; 0/Receptors, Adrenergic, alpha-2; 60-92-4/Cyclic AMP |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Development and characterization of rosin-based polymer and its application as a cream base.
Next Document: Investigations of cosmetically treated human hair by differential scanning calorimetry in water.