| An in vitro evaluation of a new plasticizer for polyvinylchloride medical devices. | |
| | |
MedLine Citation:
|
PMID: 7404643 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The rate of Hatcol-200 (H-200) leaching from polyvinylchloride (PVC) by serum is one-hundredth that of di-2-ethylhexyl phthalate (DEHP) as determined by radioassay. There is a proportional decrease in leachability of DEHP but not of H-200 as the plasma proteins are diluted. Saline extracts of DEHP demonstrated a low but progressive rate of leaching with an accumulation of 11 microgram/ml after seven weeks whereas H-200 showed only a constant residue of 0.35 microgram/ml. Normal human serum incubated for three weeks at 37 C with PVC strips plasticized with DEHP produced significant growth-inhibition of human diploid fibroblasts. Human serum incubated in an identical manner with PVC plasticized with H-200 for up to four weeks demonstrated no effect on tissue culture. These studies indicate that H-200 deserves further evaluation as a replacement for DEHP in PVC biomedical devices. |
| | |
Authors:
|
M S Jacobson; S V Kevy; R Parkman; J S Wesolowski |
Related Documents
:
|
18428993 - Body symmetry and asymmetry in early greek anatomical reasoning. 19174663 - Medical humanities and their discontents: definitions, critiques, and implications. 21844583 - Lipid droplets: size matters. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Transfusion Volume: 20 ISSN: 0041-1132 ISO Abbreviation: Transfusion Publication Date: 1980 Jul-Aug |
Date Detail:
|
Created Date: 1980-10-24 Completed Date: 1980-10-24 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0417360 Medline TA: Transfusion Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 443-7 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Diethylhexyl Phthalate
/
blood Fibroblasts Humans Plasticizers* Polyvinyl Chloride* Polyvinyls* Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Plasticizers; 0/Polyvinyls; 117-81-7/Diethylhexyl Phthalate; 9002-86-2/Polyvinyl Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cryopreservation of platelets simplified: a modified glycerol-glucose method.
Next Document: Retention of HLA antigens on previously frozen human platelets.