| The in vitro biocompatibility of self-assembled hyperbranched copolyphosphate nanocarriers. | |
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MedLine Citation:
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PMID: 20417961 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Polymeric micelles are recognized as very promising nanocarriers for small-molecule drugs, DNA, and proteins delivery. Polyphosphates are an important class of eminent biomaterials and widely used in biomedicine due to their good biocompatibility, biodegradability, and flexibility in adjusting the pendant structures. Here, some full-polyphosphate nanocarriers have been constructed successfully through self-assembly of amphiphilic hyperbranched multiarm copolymers (denoted as HPHEEP-star-PPEPs). The hydrophilic core and hydrophobic multiarm of HPHEEP-star-PPEPs are composed by hyperbranched and linear polyphosphates respectively. HPHEEP-star-PPEPs can self-assembly into nanocarriers in aqueous media with controlled size from 48 to 74 nm by conveniently adjusting the length of hydrophobic arm. These nanocarriers possess excellent biocompatibility against NIH 3T3 cells and are easily internalized by vivid cells. Chlorambucil-loaded nanocarriers were investigated for proliferation inhibition of an MDA-MB-231 breast cancer cell line in vitro, and the chlorambucil dose required for 50% cellular growth inhibition was found to be 3 microg/mL. |
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Authors:
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Jinyao Liu; Wei Huang; Yan Pang; Xinyuan Zhu; Yongfeng Zhou; Deyue Yan |
Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-24 |
Journal Detail:
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Title: Biomaterials Volume: 31 ISSN: 1878-5905 ISO Abbreviation: Biomaterials Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-05-24 Completed Date: 2010-08-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8100316 Medline TA: Biomaterials Country: England |
Other Details:
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Languages: eng Pagination: 5643-51 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, PR China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents, Alkylating / chemistry, metabolism Biocompatible Materials / chemistry*, metabolism Cell Line, Tumor Chlorambucil / chemistry, metabolism Drug Carriers / chemistry*, metabolism Humans Materials Testing Mice Micelles Molecular Structure NIH 3T3 Cells Nanostructures / chemistry* Particle Size Phosphates / chemistry*, metabolism Polymers / chemistry*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Alkylating; 0/Biocompatible Materials; 0/Drug Carriers; 0/Micelles; 0/Phosphates; 0/Polymers; 305-03-3/Chlorambucil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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