Document Detail

The in vitro biocompatibility of self-assembled hyperbranched copolyphosphate nanocarriers.
MedLine Citation:
PMID:  20417961     Owner:  NLM     Status:  MEDLINE    
Polymeric micelles are recognized as very promising nanocarriers for small-molecule drugs, DNA, and proteins delivery. Polyphosphates are an important class of eminent biomaterials and widely used in biomedicine due to their good biocompatibility, biodegradability, and flexibility in adjusting the pendant structures. Here, some full-polyphosphate nanocarriers have been constructed successfully through self-assembly of amphiphilic hyperbranched multiarm copolymers (denoted as HPHEEP-star-PPEPs). The hydrophilic core and hydrophobic multiarm of HPHEEP-star-PPEPs are composed by hyperbranched and linear polyphosphates respectively. HPHEEP-star-PPEPs can self-assembly into nanocarriers in aqueous media with controlled size from 48 to 74 nm by conveniently adjusting the length of hydrophobic arm. These nanocarriers possess excellent biocompatibility against NIH 3T3 cells and are easily internalized by vivid cells. Chlorambucil-loaded nanocarriers were investigated for proliferation inhibition of an MDA-MB-231 breast cancer cell line in vitro, and the chlorambucil dose required for 50% cellular growth inhibition was found to be 3 microg/mL.
Jinyao Liu; Wei Huang; Yan Pang; Xinyuan Zhu; Yongfeng Zhou; Deyue Yan
Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-24
Journal Detail:
Title:  Biomaterials     Volume:  31     ISSN:  1878-5905     ISO Abbreviation:  Biomaterials     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-05-24     Completed Date:  2010-08-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100316     Medline TA:  Biomaterials     Country:  England    
Other Details:
Languages:  eng     Pagination:  5643-51     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Ltd. All rights reserved.
School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, PR China.
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MeSH Terms
Antineoplastic Agents, Alkylating / chemistry,  metabolism
Biocompatible Materials / chemistry*,  metabolism
Cell Line, Tumor
Chlorambucil / chemistry,  metabolism
Drug Carriers / chemistry*,  metabolism
Materials Testing
Molecular Structure
NIH 3T3 Cells
Nanostructures / chemistry*
Particle Size
Phosphates / chemistry*,  metabolism
Polymers / chemistry*,  metabolism
Reg. No./Substance:
0/Antineoplastic Agents, Alkylating; 0/Biocompatible Materials; 0/Drug Carriers; 0/Micelles; 0/Phosphates; 0/Polymers; 305-03-3/Chlorambucil

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