Document Detail

The in situ inflammatory profile of lymphocutaneous and fixed forms of human sporotrichosis.
MedLine Citation:
PMID:  21254963     Owner:  NLM     Status:  MEDLINE    
The most common clinical presentations of sporotrichosis are the lymphocutaneous (LC) and fixed cutaneous (F) forms, but little is known about the immunopathologic differences between them. The aim of this study was to evaluate through immunohistochemistry the composition of the in situ inflammatory reaction so as to correlate the results with the clinical presentation of the disease. The following two groups of patients were involved in the studies, i.e., LC (n=19) and F (n=11) patients. Those with the LC form, in contrast to F patients, were found to have a larger number of lesions (P=0.001), of longer duration (P=0.026) and require a more extended course of treatment (P=0.049). LC patients also presented a greater fungal burden (LC:0-6.5; F:0-1.5; P=0.021), a higher percentage of neutrophils (median LC:24.7%; F:6.7%, P=0.002), CD4(+) cells (median LC:40.9%; F:30.0%, P=0.0024), CD22(+) cells (median LC:15.3%; F:2.9%, P=0.048), and higher intensity of NOS2 expression (P=0.009). Thus, our data identified differences in cell profile and inflammatory activity in lesions of LC and F forms of human sporotrichosis.
Fernanda N Morgado; Armando O Schubach; Mônica B L Barros; Fátima Conceição-Silva
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-01-24
Journal Detail:
Title:  Medical mycology     Volume:  49     ISSN:  1460-2709     ISO Abbreviation:  Med. Mycol.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-18     Completed Date:  2011-10-31     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  9815835     Medline TA:  Med Mycol     Country:  England    
Other Details:
Languages:  eng     Pagination:  612-20     Citation Subset:  IM    
Copyright Information:
© 2011 ISHAM
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MeSH Terms
CD4-Positive T-Lymphocytes / immunology
Colony Count, Microbial
Inflammation / pathology*
Lymphocyte Subsets / chemistry,  immunology
Middle Aged
Neutrophils / immunology
Sialic Acid Binding Ig-like Lectin 2 / analysis
Sporotrichosis / pathology*
Young Adult
Reg. No./Substance:
0/Sialic Acid Binding Ig-like Lectin 2

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