| An in situ evaluation of distal splenic arteriovenous fistula on pancreas function in an isolated pancreas segment. | |
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MedLine Citation:
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PMID: 2412526 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine the effects of a distal splenic arteriovenous fistula on endocrine function and pancreatic blood flow, 25 dogs underwent proximal pancreatectomy with the pancreatic tail left in situ and free intraperitoneal drainage of the pancreatic duct. Group A served as controls. In groups B through E, ligation of all nonpancreatic splenic vessels was accomplished. In group B, no further manipulations were performed. In group C, an arteriovenous fistula was created. Groups D and E were identical to groups B and C, respectively, except for the induction of bile pancreatitis. During intravenous glucose tolerance testing, the mean (+/- SEM) basal-to-peak insulin difference was 10.1 +/- 3.5 microU/mL in group A, 16.3 +/- 3.6 microU/mL in group B, 14.8 +/- 5.1 microU/mL in group C, 16.4 +/- 3.1 microU/mL in group D, and 13.0 +/- 4.4 microU/mL in group E. Corresponding mean (+/- SEM) glucose clearance values were as follows: -0.907% +/- 0.24%/min, -0.867% +/- 0.14%/min, -1.056% +/- 0.21%/min, -1.365% +/- 0.26%/min, and -0.887% +/- 0.20%/min. These values were not significantly different. Ligation of all splenic arterial and venous branches resulted in a 64.8% to 78.3% reduction in splenic artery blood flow that was restored to 60.9% to 84.9% of basal flow by an arteriovenous fistula (groups C and E). In conclusion, the creation of a splenic arteriovenous fistula was not beneficial in this model and other factors (rejection or technical) should be considered in vascular thrombosis following segmental pancreatic transplantation. |
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Authors:
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P J Garvin; M A Castaneda; M L Niehoff; K A Mauller; J J Brems |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of surgery (Chicago, Ill. : 1960) Volume: 120 ISSN: 0004-0010 ISO Abbreviation: Arch Surg Publication Date: 1985 Oct |
Date Detail:
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Created Date: 1985-10-16 Completed Date: 1985-10-16 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9716528 Medline TA: Arch Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1148-51 Citation Subset: AIM; IM |
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| MeSH Terms | |
Descriptor/Qualifier:
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Amylases
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blood Animals Dogs Female Glucose Tolerance Test Ligation Methods Pancreas / blood supply, physiology Pancreas Transplantation* Pancreatitis / physiopathology, surgery Regional Blood Flow Splenic Artery / surgery* Splenic Vein / surgery* |
| Chemical | |
Reg. No./Substance:
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EC 3.2.1.-/Amylases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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