Document Detail


The in situ dynamics of dendritic cell interactions.
MedLine Citation:
PMID:  20853494     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
DC regulate T-cell function by promoting either tolerance or activation, and in the latter case, by directing the quality of the ensuing response. New imaging tools now permit direct visualization of the relevant DC-T-cell interactions in vivo and have provided a new perspective on the dynamics of these crucial cellular contacts. In this Viewpoint, we discuss the insights generated by direct visualization of DC-T-cell interactions and the controversies/unanswered questions that need to be addressed in future work.
Authors:
Wolfgang Kastenmüller; Michael Y Gerner; Ronald N Germain
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of immunology     Volume:  40     ISSN:  1521-4141     ISO Abbreviation:  Eur. J. Immunol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-09-20     Completed Date:  2010-12-23     Revised Date:  2012-09-18    
Medline Journal Info:
Nlm Unique ID:  1273201     Medline TA:  Eur J Immunol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  2103-6     Citation Subset:  IM    
Affiliation:
Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1892, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigen Presentation
Cell Communication / immunology*
Dendritic Cells / immunology*
Humans
Immune Tolerance
Lymphocyte Activation
Mice
Microscopy / instrumentation,  methods
T-Lymphocytes / immunology
Grant Support
ID/Acronym/Agency:
ZIA AI000545-23/AI/NIAID NIH HHS; ZIA AI001034-04/AI/NIAID NIH HHS
Comments/Corrections

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