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Osteopenia/osteoporosis in patients with calcium nephrolithiasis.
MedLine Citation:
PMID:  22886308     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The objective of this study is to analyze the alterations in bone mineral density and bone and calcium-phosphorus metabolism in patients with calcium nephrolithiasis. We designed a study with 182 patients who were distributed among three groups: group O, 56 patients without nephrolithiasis; group A, 67 patients with calcium nephrolithiasis and mild lithogenic activity; and group B, 59 patients with calcium nephrolithiasis and severe lithogenic activity. Metabolic parameters of blood and urine that were related to calcium-phosphorous and bone metabolism and bone densitometry were assessed in all patients. A comparative study was performed on the variables of bone and calcium-phosphorus metabolism and bone densitometry as well as the presence or absence of osteopenia/osteoporosis. The patients in group B had a greater loss of bone mineral density, measured by the T-score, than the patients in groups O and A. Moreover, the proportion of patients in group B with osteopenia/osteoporosis was statistically significantly higher than the proportion of patients in groups O and A. We observed higher values of calciuria, fasting calcium/creatinine ratio, and 24-h calcium/creatinine among the patients in group B compared to the other two groups. Calciuria, citraturia, and fasting calcium/creatinine were independent factors that showed a relationship with severe lithogenic activity compared to the control group, and β-crosslaps is an independent factor that has a relationship with severe lithogenic activity as compared to mild lithogenic activity. Patients with calcium lithiasis and severe lithogenic activity have a greater loss in bone mineral density and therefore a greater risk of osteopenia/osteoporosis.
Authors:
Miguel Angel Arrabal-Polo; Miguel Arrabal-Martin; Maria Sierra Girón-Prieto; Antonio Poyatos-Andujar; Juan Garrido-Gomez; Armando Zuluaga-Gomez; Salvador Arias-Santiago
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-12
Journal Detail:
Title:  Urological research     Volume:  -     ISSN:  1434-0879     ISO Abbreviation:  Urol. Res.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0364311     Medline TA:  Urol Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Urology Department, San Cecilio University Hospital, Camino de Ronda Street, 143. 4F, Granada, Spain, arrabalp@ono.com.
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