Document Detail


The t(6;9)(p22;q34) in myeloid neoplasms: a retrospective study of 16 cases.
MedLine Citation:
PMID:  21156248     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Among patients with acute myeloid leukemia (AML), the t(6;9) (p22;q34) is a rare but defined subset with a poor prognosis. We report 16 patients with the t(6;9), of whom 13 had AML, 2 had myelodysplastic syndrome (MDS), and 1 had chronic myeloid leukemia in myeloid blast crisis (CML-BC). All except for one were evaluated at diagnosis. The median age was 34.5 (range: 7-62 years), with 12 adults and 12 males. Trilineage dysplasia was present in 13 (81%). Marrow basophilia was seen in only two patients, one of whom had CML-BC. HLA-DR was positive in all 12 patients assessed, CD33 in 11, CD13 in 10, and CD34 in seven. Four patients had one other abnormality apart from the t(6;9). These were the t(9;22) in the patient with CML and deletion 9q, addition 13q, and an isochromosome 8q in the other three patients. There were no complex karyotypes. Fms-related tyrosine kinase 3--internal tandem duplication (FLT3-ITD) mutations were seen in seven of 13 patients. Follow-up details were available for six patients. Three received palliative care, and follow-up details were not available for the other seven. The response to chemotherapy was poor in the remaining patients. The only patients who survived were three out of the four who had allogeneic hematopoietic stem cell transplantation (HSCT).
Authors:
Monika Gupta; J Ashok Kumar; Usha Sitaram; S Neeraj; A Nancy; Poonkuzhali Balasubramanian; Aby Abraham; Vikram Mathews; Auro Viswabandya; Biju George; Mammen Chandy; Alok Srivastava; Vivi M Srivastava
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  203     ISSN:  1873-4456     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-15     Completed Date:  2011-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  297-302     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Affiliation:
Cytogenetics Unit, Christian Medical College, Ida Scudder Road, Vellore 632004, India.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Child
Chromosomes, Human, Pair 6*
Chromosomes, Human, Pair 9*
Female
Hematopoietic Stem Cell Transplantation
Humans
Karyotyping
Leukemia, Myeloid / genetics*
Male
Middle Aged
Mutation
Retrospective Studies
Translocation, Genetic*
Transplantation, Homologous

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