| Leukemia/lymphoma in cerebrospinal fluid: distinguishing between cases that performed well and poorly in the College of American Pathologists Interlaboratory Comparison Program in Non-gynecologic Cytology. | |
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MedLine Citation:
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PMID: 17149947 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Although the cytologic features of leukemia/lymphoma in cerebrospinal fluid specimens are well known, the correlation of these features with the ability of cytologists to identify this tumor have not been well studied. OBJECTIVE: To identify the morphologic features of leukemia/lymphoma in cerebrospinal fluid that are associated with good performance and poor performance in an educational interlaboratory comparison program; and to identify the morphologic features associated with how well a slide performs with regard to its reference diagnosis. DESIGN: The performance of 147 cases of leukemia/lymphoma in the College of American Pathologists Interlaboratory Comparison Program in Non-gynecologic Cytology was analyzed. The cytologic features of a subset of 31 cases composed of relatively equal numbers of Romanowsky-stained and Papanicolaou-stained specimens were further evaluated, and those that performed poorly (n = 12) were compared with those that performed extremely well (n = 19). RESULTS: For all cases of leukemia/lymphoma in the program, the rate of misclassification as benign for cases with Papanicolaou stain was significantly higher than for those with Romanowsky stain (9.5% vs 2.6%, P < .001). Compared with cases that performed well, slides that performed poorly were more likely to have less than 200 abnormal cells (42% vs 5%, P = .02). The size of the tumor cells and preservation were not significant. CONCLUSION: Cases of specimens of leukemia/lymphoma in cerebrospinal fluid are more likely to be misdiagnosed as benign if they are Papanicolaou-stained or have 200 abnormal cells. |
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Authors:
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Andrew A Renshaw; Jonathan H Hughes; Edward Wang; Jennifer Haja; David Wilbur; Michael R Henry; Ann T Moriarty; |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of pathology & laboratory medicine Volume: 130 ISSN: 1543-2165 ISO Abbreviation: Arch. Pathol. Lab. Med. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-12-07 Completed Date: 2006-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7607091 Medline TA: Arch Pathol Lab Med Country: United States |
Other Details:
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Languages: eng Pagination: 1762-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Pathology, Baptist Hospital of Miami, Miami, Fla, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cytodiagnosis
/
methods,
standards* Diagnostic Errors / statistics & numerical data* Humans Laboratories, Hospital / standards Leukemia / cerebrospinal fluid*, diagnosis Lymphoma / cerebrospinal fluid*, diagnosis Pathology, Clinical / standards* Predictive Value of Tests Quality Assurance, Health Care Societies, Medical* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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