Document Detail


SWI/SNF in cardiac progenitor cell differentiation.
MedLine Citation:
PMID:  23606236     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiogenesis requires proper specification, proliferation, and differentiation of cardiac progenitor cells (CPCs). The differentiation of CPCs to specific cardiac cell types is likely guided by a comprehensive network comprised of cardiac transcription factors and epigenetic complexes. In this review, we describe how the ATP-dependent chromatin remodeling SWI/SNF complexes work synergistically with transcription and epigenetic factors to direct specific cardiac gene expression during CPC differentiation. Furthermore, we discuss how SWI/SNF may prime chromatin for cardiac gene expression at a genome-wide level. A detailed understanding of SWI/SNF-mediated CPC differentiation will provide important insight into the etiology of cardica defects and help design novel therapies for heart disease.
Authors:
Ienglam Lei; Liu Liu; Mai Har Sham; Zhong Wang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of cellular biochemistry     Volume:  114     ISSN:  1097-4644     ISO Abbreviation:  J. Cell. Biochem.     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-09-13     Completed Date:  2014-04-07     Revised Date:  2014-10-01    
Medline Journal Info:
Nlm Unique ID:  8205768     Medline TA:  J Cell Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2437-45     Citation Subset:  IM    
Copyright Information:
© 2013 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation / genetics,  physiology*
Chromatin Assembly and Disassembly / genetics,  physiology
Chromosomal Proteins, Non-Histone / genetics,  metabolism*
Humans
Stem Cells / cytology*,  metabolism*
Transcription Factors / genetics,  metabolism*
Grant Support
ID/Acronym/Agency:
R01 HL109054/HL/NHLBI NIH HHS; R01 HL109054‐01/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Chromosomal Proteins, Non-Histone; 0/SWI-SNF-B chromatin-remodeling complex; 0/Transcription Factors
Comments/Corrections

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