| PET/CT in the assessment of previously treated skull base malignancies. | |
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MedLine Citation:
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PMID: 19536771 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Altered anatomy, radiotherapy, hardware, and reconstructive materials distort the posttreatment ventral skull base. The diagnostic characteristics of positron emission tomography/CT (PET/CT) studies in those with suspected recurrent malignancy were assessed. METHODS: A retrospective review was undertaken of patients with head and neck cancer who had PET/CT for ventral skull base disease. RESULTS: Thirty-four PET/CTs were performed for suspected recurrent malignancy in the skull base (mean age, 59.6 +/- 10.7 years; female 38%). The group comprised mainly minor salivary (35.3%), squamous (32.3%), and neuroectodermal (23.6%) tumors. Mean clinical follow-up after PET/CT was 256 +/- 173 days. Sensitivity was 100% but specificity was 40%. Standard uptake values (SUVs) for true positives were higher than for those without disease (p = .03). CONCLUSIONS: PET/CT is a highly sensitive test for malignant disease. The mucosal lining of the reconstructed skull base is a common source for inflammatory pathologies that may lead to false-positive PET/CT. Defining SUV thresholds for malignancy may improve specificity. |
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Authors:
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Richard J Harvey; Geoff Pitzer; Daniel B Nissman; Luke Buchmann; Zoran Rumboldt; Terry Day; Rodney J Schlosser |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Head & neck Volume: 32 ISSN: 1097-0347 ISO Abbreviation: Head Neck Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-17 Completed Date: 2010-04-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8902541 Medline TA: Head Neck Country: United States |
Other Details:
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Languages: eng Pagination: 76-84 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology/Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA. richard@richardharvey.com.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Female Follow-Up Studies Head and Neck Neoplasms / pathology, radiography*, radionuclide imaging* Humans Male Middle Aged Neoplasm Recurrence, Local / pathology, radiography*, radionuclide imaging* Positron-Emission Tomography* Predictive Value of Tests Retrospective Studies Risk Assessment Sensitivity and Specificity Skull Base / radiography*, radionuclide imaging* Tomography, X-Ray Computed* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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