| Gelucire 44/14 improves fat absorption in rats with impaired lipolysis. | |
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MedLine Citation:
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PMID: 20298808 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clinically relevant fat malabsorption is usually due to impaired intestinal fat digestion (lipolysis) and/or to impaired solubilization of the lipolytic metabolites. We hypothesized that Gelucire 44/14 - a semi-solid self-micro-emulsifying excipient - could increase fat absorption. In relevant rat models for impaired lipolysis or for impaired solubilization we tested whether administration of Gelucire 44/14 enhanced fat absorption. Rats with impaired lipolysis (lipase inhibitor Orlistat diet) and rats with reduced solubilization (permanent bile diversion) underwent a 72 h fat balance test to assess fat absorption. The absorption kinetics of a stable isotope-labeled fatty acid was assessed in rats with reduced solubilization, in the presence or absence of Gelucire 44/14. Gelucire 44/14 improved fat absorption in rats with impaired lipolysis (from 70% to 82%, p<0.001). In rats with reduced solubilization, Gelucire 44/14 did not increase fat absorption nor did it reconstitute the absorption kinetics of (13)C-labeled palmitate, compared with control rats administered buffer without Gelucire 44/14. The present data show that Gelucire 44/14 might enhance fat absorption under conditions of impaired lipolysis, but not during impaired solubilization. We speculate that, due to its self-micro-emulsification properties, Gelucire 44/14 stabilizes and improves residual lipolytic enzyme activity in vivo, which could be of therapeutic value in clinical conditions of fat malabsorption due to impaired lipolysis. |
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Authors:
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S Lukovac; K E R Gooijert; P C Gregory; G Shlieout; F Stellaard; E H H M Rings; H J Verkade |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-16 |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 1801 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-04-19 Completed Date: 2010-06-24 Revised Date: 2010-09-14 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 665-73 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Pediatric Gastroenterology, Department of Pediatrics, Beatrix Children's Hospital, Groningen University Institute for Drug Exploration (GUIDE), Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Fats / metabolism* Intestinal Absorption Lipolysis* Male Polyethylene Glycols* Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Fats; 0/Polyethylene Glycols; 121548-04-7/gelucire 44-14 |
| Comments/Corrections | |
Erratum In:
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Biochim Biophys Acta. 2010 Sep;1801(9):1105 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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