Document Detail

Is improvement in the quality of life after subthalamic nucleus stimulation in Parkinson's disease predictable?
MedLine Citation:
PMID:  22170276     Owner:  NLM     Status:  In-Data-Review    
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) significantly improves quality of life (QoL) in PD. However, QoL fails to improve in a relevant proportion of patients. We studied clinical baseline and progression parameters associated with improvement in QoL after DBS. Data from a German randomized, controlled study comparing DBS (60 patients) with best medical treatment (59 patients) were analyzed. Changes in patients' QoL were assessed using the Parkinson's Disease Questionnaire (PDQ-39) at baseline and at the 6-month follow-up. For the STN-DBS patients, the changes in PDQ-39 were correlated with predefined clinical preoperative and progression parameters. Scores for QoL improved after STN-DBS for 57% of the patients, and for 43% patients, they did not improve. Patients with improvement in QoL showed significantly higher cumulative daily "off" time. Changes in the PDQ-39 showed a significant positive correlation with the cumulative daily off time at baseline. Logistic regression analysis revealed that 1 additional hour off time at baseline increases the odds for improvement on PDQ-39 by a factor of 1.33 (odds ratio). In the postoperative course, changes in the PDQ-39 significantly correlated with the reduction of cumulative daily off time, an improvement on the UPDRS (UPDRS III off), and positive mood changes. Among the baseline parameters, the cumulative daily off time is the strongest predictor for improvement in disease-related QoL after DBS. Improvement in QoL after STN-DBS is also correlated with changes in motor functions and changes in depression and anxiety. © 2011 Movement Disorder Society.
Christine Daniels; Paul Krack; Jens Volkmann; Jan Raethjen; Markus O Pinsker; Manja Kloss; Volker Tronnier; Alfons Schnitzler; Lars Wojtecki; Kai Bötzel; Adrian Danek; Rüdiger Hilker; Volker Sturm; Andreas Kupsch; Elfriede Karner; Günther Deuschl; Karsten Witt
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Publication Detail:
Type:  Journal Article     Date:  2011-08-25
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  26     ISSN:  1531-8257     ISO Abbreviation:  Mov. Disord.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2516-21     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Movement Disorder Society.
Department of Neurology, Christian-Albrechts-University, Kiel, Germany.
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