Document Detail

An improved technique for nasal inhalation challenge tests.
MedLine Citation:
PMID:  1249349     Owner:  NLM     Status:  MEDLINE    
An improved technique for nasal inhalation challenge tests is described. It includes an improved delivery system utilizing a Maxi-Myst air compressor delivering a flow of room air controlled by an in-line, electroncially timed solenoid which precisely controls the duration of compressor activity. A No. 251 DeVilbiss atomizer will deliver 0.1 + 0.01 gm/spray when the flow rate is 11.5 L/min, the duration of atomizer activity is approximately 0.1 sec, and the amount of liquid in the atomizer insert is kept between 0.75 and 2.0 ml. Nasal aerosol challenge of 0.1 ml of isotonic phosphate-buffered saline per nostril produced less variability in nasal airway resistance (NAR) response than 0.2 ml, and the smaller volume proved satisfactory for 6 consecutive saline challenges at 15-min intervals. A new face mask, which did not impinge on the bridge of the nose or paranasal structures, yielded lower baseline values of nasal airway resistance and much less variability in these measurements. Techniques employed in objectively quantitating nasal responses to various exogenous substances are briefly but critically reviewed.
J A McLean; A A Ciarkowski; W R Solomon; K P Mathews
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  57     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  1976 Feb 
Date Detail:
Created Date:  1976-04-15     Completed Date:  1976-04-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  153-63     Citation Subset:  AIM; IM    
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MeSH Terms
Administration, Intranasal
Airway Resistance / drug effects*
Respiratory Function Tests / instrumentation
Sodium Chloride / pharmacology
Reg. No./Substance:
0/Aerosols; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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