| An improved source of bryostatin 10, Bugula neritina from the Gulf of Aomori, Japan. | |
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MedLine Citation:
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PMID: 8691208 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bryostatins have been isolated from diverse Japanese coastal specimens of Bugula neritina guided by inhibitory activity against fertilized sea urchin egg cell division. B. neritina from the Gulf of Aomori, Japan, has been found to contain bryostatin 10 [1b] in high yield (10(-3)%) for this class of compounds. The 1H- and 13C-nmr signals of bryostatin 10 [1b] were reassigned by 2D nmr techniques. The conformation of bryostatin 10 [1b] in solution was revealed by nmr studies. This compound also exhibited activity in a steroidogenesis assay by increasing the production of adrenocortical hormones nearly twofold. |
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Authors:
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Y Kamano; H P Zhang; A Hino; M Yoshida; G R Pettit; C L Herald; H Itokawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of natural products Volume: 58 ISSN: 0163-3864 ISO Abbreviation: J. Nat. Prod. Publication Date: 1995 Dec |
Date Detail:
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Created Date: 1996-08-26 Completed Date: 1996-08-26 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7906882 Medline TA: J Nat Prod Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1868-75 Citation Subset: IM |
Affiliation:
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Faculty of Science, Kanagawa University, Hiratsuka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bryostatins Bryozoa / chemistry* Cattle Cells, Cultured Japan Lactones / chemistry, isolation & purification* Macrolides Magnetic Resonance Spectroscopy Molecular Conformation Steroids / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Bryostatins; 0/Lactones; 0/Macrolides; 0/Steroids; 102580-65-4/bryostatin 10 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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