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An improved model to predict physiologically based model parameters and their inter-individual variability from anthropometry.
MedLine Citation:
PMID:  22954170     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We developed a population physiology model, physB, which provides a statistical description of the physiological characteristics in the human population, in terms of the physiological parameters that are needed in physiologically based pharmacokinetic modelling. The model predicts individual organ weights, blood flows and some respiratory parameters from anthropometric properties (body height and weight, age and gender). It draws on two existing models, PK-Pop and P((3))M, but various changes and improvements were made. The conceptual differences among the three models are discussed and they are quantitatively compared by running all three models for various specific combinations of anthropometric properties.
Authors:
Sieto Bosgra; Jan van Eijkeren; Peter Bos; Marco Zeilmaker; Wout Slob
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-7
Journal Detail:
Title:  Critical reviews in toxicology     Volume:  -     ISSN:  1547-6898     ISO Abbreviation:  Crit. Rev. Toxicol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8914275     Medline TA:  Crit Rev Toxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Institute for Risk Assessment Sciences (IRAS), Utrecht University , P.O. Box 80.178, NL 3508, Utrecht , The Netherlands.
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