| An improved method for the analysis of data from radiation-inactivation studies. | |
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MedLine Citation:
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PMID: 2363496 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This paper addresses statistical issues in the estimation of protein molecular weight using radiation-inactivation assays. In particular it considers experiments in which a number of internal standards are used to supplement or replace accurate measurement of the applied doses of radiation. A mathematical model is proposed which allows the use of the standard technique of maximum-likelihood estimation to estimate the unknown molecular weight without knowledge of the applied doses and, in contrast to previous methods, allows the construction of confidence intervals. |
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Authors:
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I Bradbury; V A Zammit |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Analytical biochemistry Volume: 186 ISSN: 0003-2697 ISO Abbreviation: Anal. Biochem. Publication Date: 1990 May |
Date Detail:
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Created Date: 1990-08-08 Completed Date: 1990-08-08 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370535 Medline TA: Anal Biochem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 251-6 Citation Subset: IM |
Affiliation:
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Scottish Agricultural Statistics Service, Edinburgh. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carnitine O-Palmitoyltransferase / metabolism Confidence Intervals Malonyl Coenzyme A / metabolism Mathematics Membrane Proteins / radiation effects Mitochondria, Liver / enzymology Molecular Weight* Proteins / radiation effects* Rats Reference Standards |
| Chemical | |
Reg. No./Substance:
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0/Membrane Proteins; 0/Proteins; 524-14-1/Malonyl Coenzyme A; EC 2.3.1.21/Carnitine O-Palmitoyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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