Document Detail


An improved method for the analysis of data from radiation-inactivation studies.
MedLine Citation:
PMID:  2363496     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This paper addresses statistical issues in the estimation of protein molecular weight using radiation-inactivation assays. In particular it considers experiments in which a number of internal standards are used to supplement or replace accurate measurement of the applied doses of radiation. A mathematical model is proposed which allows the use of the standard technique of maximum-likelihood estimation to estimate the unknown molecular weight without knowledge of the applied doses and, in contrast to previous methods, allows the construction of confidence intervals.
Authors:
I Bradbury; V A Zammit
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Analytical biochemistry     Volume:  186     ISSN:  0003-2697     ISO Abbreviation:  Anal. Biochem.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-08-08     Completed Date:  1990-08-08     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370535     Medline TA:  Anal Biochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  251-6     Citation Subset:  IM    
Affiliation:
Scottish Agricultural Statistics Service, Edinburgh.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carnitine O-Palmitoyltransferase / metabolism
Confidence Intervals
Malonyl Coenzyme A / metabolism
Mathematics
Membrane Proteins / radiation effects
Mitochondria, Liver / enzymology
Molecular Weight*
Proteins / radiation effects*
Rats
Reference Standards
Chemical
Reg. No./Substance:
0/Membrane Proteins; 0/Proteins; 524-14-1/Malonyl Coenzyme A; EC 2.3.1.21/Carnitine O-Palmitoyltransferase

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