Document Detail

An improved method for Y-body identification and confirmation of a high incidence of YY sperm nuclei.
MedLine Citation:
PMID:  6169625     Owner:  NLM     Status:  MEDLINE    
The fluorescence of Y-bodies and brightly fluorescing autosomal heterochromatin in quinacrine mustard stained interphase nuclei treated with distamycin A is more brilliant than in nuclei stained only with quinacrine and mustard. In the present study examinations with the aid of this method in several probands and different tissues are described. The effect of distamycin A is demonstrated to depend on its dose and the time of exposure to it. An exceptionally high frequency of YY sperm nuclei, previously also described by other studies, is confirmed in the present work. A hypothesis explaining the effect of distamycin A in interphase nuclei is discussed.
M Klasen; M Schmid
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human genetics     Volume:  58     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1981  
Date Detail:
Created Date:  1981-12-21     Completed Date:  1981-12-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  156-61     Citation Subset:  IM    
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MeSH Terms
Cell Nucleus / ultrastructure
Fibroblasts / ultrastructure
Heterochromatin / analysis*
Lymphocytes / ultrastructure
Quinacrine Mustard
Sex Chromosomes*
Spermatozoa / ultrastructure*
Staining and Labeling
Y Chromosome*
Reg. No./Substance:
0/Distamycins; 0/Heterochromatin; 4213-45-0/Quinacrine Mustard

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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