Document Detail

An improved mechanical air puff stimulator that allows activation of a variety of endoepithelial receptors and is suitable for the study of reflexes in animals and humans.
MedLine Citation:
PMID:  9489887     Owner:  NLM     Status:  MEDLINE    
Studies of endoepithelial-triggered reflexes, such as nasal respiratory reflexes, are difficult to carry out in humans without a non-traumatic and reliable stimulation device. The air puff stimulator described allows us to deliver air puffs of brief duration at various intensities, frequencies, and temperatures. The stimulation is non-traumatizing and non-nociceptive. We have successfully used it in animals as a source of specific stimuli to enable us to study central and peripheral neuronal responses evoked by activation of endonasal dynamically sensitive receptors. Immunohistochemical studies of the c-fos expression evoked during sneezing elicited by air puffs provided additional evidence for the specificity of this particular stimulation technique. We suggest that the use of such a non-traumatizing air puff stimulator could be extended to human studies. It might be particularly useful in developmental studies of endoepithelial-triggered reflexes such as those respiratory reflexes whose immaturity at birth can be life-threatening.
F Wallois; A Lebeon; B Duron
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of neuroscience methods     Volume:  77     ISSN:  0165-0270     ISO Abbreviation:  J. Neurosci. Methods     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-04-08     Completed Date:  1998-04-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905558     Medline TA:  J Neurosci Methods     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  119-27     Citation Subset:  IM    
Laboratoire de Neurophysiologie, CNRS URA 1331, Faculté de Médecine, Université de Picardie Jules Verne, Amiens, France.
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MeSH Terms
Electronics, Medical / instrumentation
Endothelium / physiology*
Epithelial Cells / physiology*
Equipment Design / instrumentation
Physical Stimulation / instrumentation*,  methods
Receptors, Cell Surface / physiology*
Reflex / physiology*
Sneezing / physiology*
Reg. No./Substance:
0/Receptors, Cell Surface

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