Document Detail

The imprecision arising from the application of the Henderson-Hasselbalch relationship to the blood of anesthetized dogs.
MedLine Citation:
PMID:  5145729     Owner:  NLM     Status:  MEDLINE    
1. Arterial blood samples were obtained from anaesthetized dogs in which either a respiratory alkalaemia, a respiratory acidaemia or a non-respiratory acidaemia was produced and from animals in which no deliberate changes in acid-base balance were produced. The samples were analysed for pH, carbon dioxide tension and concentration, oxygen tension and concentration and haematocrit. From these determinations the plasma carbon dioxide concentration, the plasma bicarbonate ion concentration and pK' were calculated.2. The value of pK' lay within the range 5.86-6.27. The temperatures of the animals studied were between 36.75 and 39.25 degrees C but there was no significant relationship between pK' and temperature.3. The values of pK' increased with an alkalaemia and decreased with an acidaemia.4. In addition to the variation of pK' with pH there was a considerable residual scatter of pK' values at any one pH value.5. It was concluded that in these experimental conditions the use of the Henderson-Hasselbalch equation in a form not dealing with activities was unacceptable and could lead to much larger errors than has hitherto been thought.
R J Linden; J Norman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of physiology     Volume:  215     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  1971 Jun 
Date Detail:
Created Date:  1972-06-19     Completed Date:  1972-06-19     Revised Date:  2010-09-13    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  491-507     Citation Subset:  IM    
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MeSH Terms
Acid-Base Equilibrium*
Acidosis / physiopathology
Acidosis, Respiratory / physiopathology
Alkalosis, Respiratory / physiopathology
Anesthesia, General*
Anesthesia, Inhalation
Anesthesia, Intravenous
Bicarbonates / blood
Body Temperature
Carbon Dioxide / blood
Hydrochloric Acid / pharmacology
Hydrogen-Ion Concentration
Hypercapnia / physiopathology
Models, Biological*
Oxygen / blood
Respiration, Artificial
Reg. No./Substance:
0/Bicarbonates; 124-38-9/Carbon Dioxide; 15879-93-3/Chloralose; 76-74-4/Pentobarbital; 7647-01-0/Hydrochloric Acid; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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