| The imprecision arising from the application of the Henderson-Hasselbalch relationship to the blood of anesthetized dogs. | |
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MedLine Citation:
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PMID: 5145729 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Arterial blood samples were obtained from anaesthetized dogs in which either a respiratory alkalaemia, a respiratory acidaemia or a non-respiratory acidaemia was produced and from animals in which no deliberate changes in acid-base balance were produced. The samples were analysed for pH, carbon dioxide tension and concentration, oxygen tension and concentration and haematocrit. From these determinations the plasma carbon dioxide concentration, the plasma bicarbonate ion concentration and pK' were calculated.2. The value of pK' lay within the range 5.86-6.27. The temperatures of the animals studied were between 36.75 and 39.25 degrees C but there was no significant relationship between pK' and temperature.3. The values of pK' increased with an alkalaemia and decreased with an acidaemia.4. In addition to the variation of pK' with pH there was a considerable residual scatter of pK' values at any one pH value.5. It was concluded that in these experimental conditions the use of the Henderson-Hasselbalch equation in a form not dealing with activities was unacceptable and could lead to much larger errors than has hitherto been thought. |
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Authors:
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R J Linden; J Norman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of physiology Volume: 215 ISSN: 0022-3751 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 1971 Jun |
Date Detail:
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Created Date: 1972-06-19 Completed Date: 1972-06-19 Revised Date: 2010-09-13 |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 491-507 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acid-Base Equilibrium* Acidosis / physiopathology Acidosis, Respiratory / physiopathology Alkalosis, Respiratory / physiopathology Anesthesia, General* Anesthesia, Inhalation Anesthesia, Intravenous Animals Bicarbonates / blood Body Temperature Carbon Dioxide / blood Chloralose Dogs Hematocrit Hydrochloric Acid / pharmacology Hydrogen-Ion Concentration Hypercapnia / physiopathology Models, Biological* Oxygen / blood Pentobarbital Respiration, Artificial |
| Chemical | |
Reg. No./Substance:
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0/Bicarbonates; 124-38-9/Carbon Dioxide; 15879-93-3/Chloralose; 76-74-4/Pentobarbital; 7647-01-0/Hydrochloric Acid; 7782-44-7/Oxygen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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