Document Detail

The important role of left ventricular relaxation and left atrial pressure in the left ventricular filling velocity profile.
MedLine Citation:
PMID:  2683699     Owner:  NLM     Status:  MEDLINE    
To evaluate the determinants of left ventricular filling, left ventricular filling velocity was measured by pulsed Doppler flowmetry during catheterization of the right and left sides of the heart in 37 patients with cardiac disease before and during leg elevation. During leg elevation, despite no significant change in the time constant of isovolumic relaxation (T), the peak rapid filling velocity (PVRF) increased in association with an increase in pulmonary wedge pressure (PWP), but the peak atrial filling velocity was unchanged. The PVRF correlated with the pulmonary wedge V wave - left ventricular minimum pressure difference (r = 0.68) and in multivariate regression with both T and mean PWP (R = 0.73). These results indicate that left ventricular filling is determined by both left ventricular relaxation and left atrial pressure and that an increase in left atrial pressure changes the left ventricular filling velocity profile in a manner that mimics the pattern with normal diastolic function.
S Takagi; M Yokota; M Iwase; J Yoshida; H Hayashi; I Sotobata; M Koide; H Saito
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  118     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1989-12-05     Completed Date:  1989-12-05     Revised Date:  2006-02-27    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  954-62     Citation Subset:  AIM; IM    
First Department of Internal Medicine, Nagoya University School of Medicine, Japan.
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MeSH Terms
Blood Flow Velocity
Blood Pressure*
Coronary Circulation*
Heart / physiopathology*
Heart Atria
Heart Diseases / physiopathology
Heart Ventricles
Leg / physiology
Middle Aged
Mitral Valve / physiopathology
Multivariate Analysis
Myocardial Contraction*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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