Document Detail


The importance of urinary immunoglobulin light chain isoelectric point (pI) in nephrotoxicity in multiple myeloma.
MedLine Citation:
PMID:  6420108     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is clinical and experimental evidence to imply that urinary immunoglobulin light chains are nephrotoxic yet some patients pass large amounts for years with little renal damage. Animal experiments suggest that a light chain is more nephrotoxic if it has a high isoelectric point (i.e. is cationic in relation to urine pH). We studied 23 patients with multiple myeloma, measuring light chain excretion rate, light chain isoelectric point (pI) and creatinine clearance. Light chain excretion rate was independent of light chain isoelectric point and did not correlate with creatinine clearance. Light chain isoelectric point correlated with creatinine clearance, suggesting that this characteristic may be an important determinant of the nephrotoxic effect of these immunoglobulin constituents.
Authors:
R A Coward; I W Delamore; N P Mallick; E L Robinson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  66     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1984 Feb 
Date Detail:
Created Date:  1984-03-14     Completed Date:  1984-03-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  229-32     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Creatinine / urine
Female
Humans
Immunoglobulin Light Chains / urine*
Isoelectric Point
Kidney Diseases / etiology*
Male
Middle Aged
Multiple Myeloma / complications*,  immunology,  urine
Chemical
Reg. No./Substance:
0/Immunoglobulin Light Chains; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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