Document Detail

The importance of the time of digitalization for the incidence of spasms evoked by ouabain in strips of human saphenous vein.
MedLine Citation:
PMID:  6183768     Owner:  NLM     Status:  MEDLINE    
The extent of contracture induced by ouabain on preparations of the greater saphenous vein obtained from patients undergoing elective coronary bypass surgery was investigated. The medical pretreatment of the various donor patients was similar but differed with regard to the duration of preoperative digitalization ranging from several days to months. Whereas the maximal contraction induced by noradrenaline was not influenced by prior digitalization, the contracture evoked by ouabain showed a strong dependency on the duration of preoperative digitalization. In patients without or with only short-term preoperative digitalization the spasm exerted by ouabain amounted to 48.8% and 49.2%, respectively, of the maximal contraction induced by noradrenaline, and decreased to zero in patients with long-term digitalization. From this result it is concluded that, in patients after coronary artery bypass grafting who did not receive cardiac glycosides for long-term treatment, the acute administration of glycosides may be a mechanism responsible for the early occlusion of saphenous vein bypass grafts.
H R Zerkowski; J Wagner
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  The Thoracic and cardiovascular surgeon     Volume:  30     ISSN:  0171-6425     ISO Abbreviation:  Thorac Cardiovasc Surg     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1983-01-19     Completed Date:  1983-01-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7903387     Medline TA:  Thorac Cardiovasc Surg     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  250-2     Citation Subset:  IM    
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MeSH Terms
Coronary Artery Bypass*
Digitalis Glycosides / administration & dosage,  therapeutic use*
Middle Aged
Muscle Contraction / drug effects
Muscle, Smooth, Vascular / drug effects*
Ouabain / pharmacology*
Postoperative Complications / chemically induced
Saphenous Vein / drug effects*,  transplantation
Stimulation, Chemical
Time Factors
Reg. No./Substance:
0/Digitalis Glycosides; 630-60-4/Ouabain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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