Document Detail


The importance of thrombotic risk factors in the development of idiopathic sudden hearing loss.
MedLine Citation:
PMID:  18160602     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Impaired cochlear blood circulation has been suggested to cause sudden hearing loss. In this study, the role of factor V 1691 G-A (FV 1691 G-A), prothrombin 20210 G-A (PT 20210 G-A), methylene tetrahydrofolate reductase 677 C-T (MTHFR 677 C-T), factor V 4070 A-G (FV 4070 A-G), endothelial cell protein C receptor (EPCR) gene 23-bp insertion, and plasminogen activator inhibitor-1 (PAI-1) 4G/5G mutation was assessed. Fifty-three patients with idiopathic sudden sensorineural hearing loss and 80 individuals comprising the control group were included in this study. The frequency for FV 1691 A was 6.2% in the patient group and 3.7% in the control group, PT 20210 G-A was 1.2% in the patient group and 1.9% in the control group, and FV 4070 A-G was 7.5% in the patient group and 11.3% in the control group. The frequency of MTHFR 677 C-T was significantly higher in the patient group than in the control group, with a P value of .03. PAI-1-675 4G/5G polymorphism was found to be 71.2% and 69.8%, in the control group and the patient group, respectively. The EPCR 23-bp insertion was 0% in the control group and was found in 3 patients (3.7%), which needs further study.
Authors:
Zuleyha Yildiz; Arzu Ulu; Armagan Incesulu; Yalcin Ozkaptan; Nejat Akar
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-12-26
Journal Detail:
Title:  Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis     Volume:  14     ISSN:  1076-0296     ISO Abbreviation:  Clin. Appl. Thromb. Hemost.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-30     Completed Date:  2008-09-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508125     Medline TA:  Clin Appl Thromb Hemost     Country:  United States    
Other Details:
Languages:  eng     Pagination:  356-9     Citation Subset:  IM    
Affiliation:
Department of Pediatric Molecular Genetics, Medical School of Ankara University, Ankara, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antigens, CD / genetics
Case-Control Studies
Child
Child, Preschool
Factor V / genetics
Female
Hearing Loss, Sudden / blood,  etiology*,  genetics*
Humans
Male
Methylenetetrahydrofolate Reductase (NADPH2) / genetics
Middle Aged
Mutagenesis, Insertional
Plasminogen Activator Inhibitor 1 / genetics
Point Mutation
Prothrombin / genetics
Receptors, Cell Surface / genetics
Risk Factors
Thrombosis / blood,  complications*,  genetics*
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/PROCR protein, human; 0/Plasminogen Activator Inhibitor 1; 0/Receptors, Cell Surface; 0/SERPINE1 protein, human; 0/factor V Leiden; 9001-24-5/Factor V; 9001-26-7/Prothrombin; EC 1.5.1.20/Methylenetetrahydrofolate Reductase (NADPH2)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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