| The importance of thrombotic risk factors in the development of idiopathic sudden hearing loss. | |
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MedLine Citation:
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PMID: 18160602 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Impaired cochlear blood circulation has been suggested to cause sudden hearing loss. In this study, the role of factor V 1691 G-A (FV 1691 G-A), prothrombin 20210 G-A (PT 20210 G-A), methylene tetrahydrofolate reductase 677 C-T (MTHFR 677 C-T), factor V 4070 A-G (FV 4070 A-G), endothelial cell protein C receptor (EPCR) gene 23-bp insertion, and plasminogen activator inhibitor-1 (PAI-1) 4G/5G mutation was assessed. Fifty-three patients with idiopathic sudden sensorineural hearing loss and 80 individuals comprising the control group were included in this study. The frequency for FV 1691 A was 6.2% in the patient group and 3.7% in the control group, PT 20210 G-A was 1.2% in the patient group and 1.9% in the control group, and FV 4070 A-G was 7.5% in the patient group and 11.3% in the control group. The frequency of MTHFR 677 C-T was significantly higher in the patient group than in the control group, with a P value of .03. PAI-1-675 4G/5G polymorphism was found to be 71.2% and 69.8%, in the control group and the patient group, respectively. The EPCR 23-bp insertion was 0% in the control group and was found in 3 patients (3.7%), which needs further study. |
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Authors:
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Zuleyha Yildiz; Arzu Ulu; Armagan Incesulu; Yalcin Ozkaptan; Nejat Akar |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-12-26 |
Journal Detail:
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Title: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis Volume: 14 ISSN: 1076-0296 ISO Abbreviation: Clin. Appl. Thromb. Hemost. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-06-30 Completed Date: 2008-09-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508125 Medline TA: Clin Appl Thromb Hemost Country: United States |
Other Details:
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Languages: eng Pagination: 356-9 Citation Subset: IM |
Affiliation:
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Department of Pediatric Molecular Genetics, Medical School of Ankara University, Ankara, Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antigens, CD / genetics Case-Control Studies Child Child, Preschool Factor V / genetics Female Hearing Loss, Sudden / blood, etiology*, genetics* Humans Male Methylenetetrahydrofolate Reductase (NADPH2) / genetics Middle Aged Mutagenesis, Insertional Plasminogen Activator Inhibitor 1 / genetics Point Mutation Prothrombin / genetics Receptors, Cell Surface / genetics Risk Factors Thrombosis / blood, complications*, genetics* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/PROCR protein, human; 0/Plasminogen Activator Inhibitor 1; 0/Receptors, Cell Surface; 0/SERPINE1 protein, human; 0/factor V Leiden; 9001-24-5/Factor V; 9001-26-7/Prothrombin; EC 1.5.1.20/Methylenetetrahydrofolate Reductase (NADPH2) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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