Document Detail


The importance of sweet taste and caloric content in the effects of nicotine on specific food consumption.
MedLine Citation:
PMID:  3931146     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is an inverse relationship between nicotine and body weight that has been partially explained by changes in consumption of sweet-tasting high calorie foods. The present research was designed to determine the relative importance of sweet taste and caloric content in the effects of nicotine on specific food consumption and body weight. Alzet miniosmotic pumps were implanted SC to administer saline or two different concentrations of nicotine to 63 male Sprague-Dawley rats for 17 days. Three experiments were performed in which animals had access to two foods, a nonsweet low calorie food and a "target" food (sweet low calorie, sweet high calorie, or nonsweet high calorie). Body weight, food consumption, and water consumption were measured daily before, during, and after drug administration. In all three experiments, there was an inverse relationship between nicotine and body weight. Both sweet taste and caloric content were involved in the effects of nicotine on specific food consumption and body weight, but sweet taste was particularly important. In fact, the effects of nicotine on body weight were attenuated when sweet-tasting low calorie foods were available. These findings have implications for controlling body weight gains after cessation of cigarette smoking.
Authors:
N E Grunberg; D J Bowen; V A Maycock; S M Nespor
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Psychopharmacology     Volume:  87     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  1985  
Date Detail:
Created Date:  1985-11-19     Completed Date:  1985-11-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  198-203     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight / drug effects
Drinking Behavior / drug effects
Energy Intake / drug effects*
Feeding Behavior / drug effects*
Male
Nicotine / pharmacology*
Rats
Rats, Inbred Strains
Sweetening Agents / pharmacology
Taste / physiology*
Chemical
Reg. No./Substance:
0/Sweetening Agents; 54-11-5/Nicotine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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