Document Detail

The importance of sonographic endometrial parameters in influencing success following embryo transfer in the modern era and therapeutic options--part 1: the importance of late proliferative phase endometrial thickness.
MedLine Citation:
PMID:  21995142     Owner:  NLM     Status:  In-Process    
PURPOSE: To evaluate the importance in the modern era of either too thin or too thick of an endometrium in the late proliferative phase on success following embryo transfer.
METHODS: Pregnancy rates following fresh embryo transfer in cycles using controlled ovarian hyperstimulation and following donor egg or frozen embryo transfers using artificial estrogen-replaced cycles according to endometrial thickness were determined.
RESULTS: A thin endometrium has a negative impact on success following embryo transfer but improvement in IVF technology makes this confounding variable much less important than in the early days of IVF. Too thick of an endometrium does not seem to negatively impact success.
CONCLUSIONS: Treatment options, e.g., low-dose aspirin, sildenafil or vaginal estradiol are of marginal value in improving endometrial thickness or outcome. For those with a good frozen embryo program the best option may be to cryopreserve all embryos and transfer in a subsequent graduated estrogen/progesterone replacement cycle.
J H Check
Publication Detail:
Type:  Editorial    
Journal Detail:
Title:  Clinical and experimental obstetrics & gynecology     Volume:  38     ISSN:  0390-6663     ISO Abbreviation:  Clin Exp Obstet Gynecol     Publication Date:  2011  
Date Detail:
Created Date:  2011-10-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802110     Medline TA:  Clin Exp Obstet Gynecol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  197-200     Citation Subset:  IM    
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