| The importance of renal vascular tone in determining the severity of renal artery stenosis in dogs. | |
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MedLine Citation:
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PMID: 7441556 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The effects of the state of renal vascular tone during induction of renal artery stenosis on the subsequent systemic blood pressure and renin responses have been studied in chronically instrumented, conscious dogs. 2. In one group of dogs, renal vascular tone was altered by brief (2-3 min) renal artery infusions of ACh, saline, methoxamine or angiotensin II during narrowing of the renal artery to reduce distal pressure to 40 mmHg. The infusions were turned off 1 min later. 3. The more vasoconstricted the kidney at the time of stenosis, the slower was the restoration of distal renal artery pressure and the greater the rises in systemic blood pressure, plasma renin activity (PRA) and effective stenosis resistance. At the end of 1 hr of stenosis, the rises in systemic blood pressure were 4.3 +/- 3.3, 11.3 +/- 3.3, 28.9 +/- 3.3 and 26.3 +/- 2.8 mmHg for the ACh, saline, methoxamine and angiotensin II-infused dogs respectively; rises in PRA were 0.3 +/- 0.24, 1.18 +/- 0.42, 5.09 +/- 1.38 and 4.02 +/- 0.74 ng/ml. per hr respectively. 4. In another group of dogs a given aortic-renal artery pressure gradient was produced on two occasions: (i) with the animal conscious; (ii) under brief sodium pentobarbitone anaesthesia and preparation for surgery. After 24 hr systemic blood pressure had risen by 15.7 +/- 3.6 mmHg above initial values when stenosis was induced under anaesthesia (P < 0.05) and only by 1.2 +/- 3.6 mmHg (N.S.) when it was induced with the animal conscious. Corresponding rises in PRA were 1.29 +/- 0.42 (P < 0.05) and 0.25 +/- 0.11 (N.S.) ng/ml. per hr. Establishment of a given gradient in the high vascular resistance kidney of the anaesthetized dog thus requires greater narrowing of the renal artery than in the lower resistance renal bed of the conscious animal. 5. The tone of the renal vascular bed is a major determinant of the severity of renal artery stenosis. |
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Authors:
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W P Anderson; P I Korner |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of physiology Volume: 305 ISSN: 0022-3751 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 1980 Aug |
Date Detail:
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Created Date: 1981-02-19 Completed Date: 1981-02-19 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 31-41 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia, Intravenous Animals Blood Pressure Dogs Kidney / blood supply*, drug effects Pentobarbital / pharmacology Regional Blood Flow / drug effects Renal Artery Obstruction / physiopathology* Vascular Resistance Vasoconstrictor Agents / pharmacology Vasodilator Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Vasoconstrictor Agents; 0/Vasodilator Agents; 76-74-4/Pentobarbital |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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